CGRP monoclonal antibodies in the treatment of migraine – indication criteria and therapeutic recommendations for the Czech Republic

Authors: T. Nežádal- 1 4;  J. Marková 4,5;  A. Bártková 4,6;  L. Klečka- 4 7
Authors‘ workplace: Neurologické oddělení, ÚVN-VFN Praha 1;  Institut neuropsychiatrické péče, Praha 2;  Neurochirurgická klinika, 1. LF UK, Praha 3;  Sekce pro diagnostiku a léčbu bolesti, hlavy ČNS ČLS JEP 4;  Neurologická klinika 3. LF UK, a Thomayerovy nemocnice, Praha 5;  Neurologická klinika LF UP, a FN Olomouc 6;  Neurologické oddělení, Městská nemocnice Ostrava 7
Published in: Cesk Slov Neurol N 2020; 83/116(4): 445-451
doi: 10.14735/amcsnn2020445


Current prophylactic treatment of frequent episodic and chronic migraine is often unsuccessful or associated with adverse events. Calcitonin gene-related peptide (CGRP) is a key peripheral and central patophysiological agent in migraine. Data emerging from trials with monoclonal antibodies suggest that specific blockade of the CGRP pathway may provide an effective and treatment in migraine. At present, precise indication criteria for the administration of these antibodies, required duration of their administration and methods of evaluating their effect, especially on the quality of life, are being determined.


Migraine – prophylactic treatment – antibodies CGRP – guidelines


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