The Brain Metastasis of a Large-Cell Neuroendocrine Thymic Cancer: a Case Report


Authors: T. Zeman 1;  J. Chrastina 1;  Z. Novák 1;  I. Zichová. 2;  J. Hemza 1
Authors‘ workplace: Neurochirurgická klinika FN U sv. Anny, Brno 1;  Patologicko-anatomický ústav FN U sv. Anny, Brno 2
Published in: Cesk Slov Neurol N 2007; 70/103(3): 332-335
Category: Case Report

Overview

The paper reports on an exceptional case of a patient with the brain metastasis of large-cell neuroendocrine thymic cancer. A 61-year-old female was admitted for gradually progressive leftsided hemiparesis with subsequent deterioration of consciousness, two years after a surgery for thymic cancer. The initial CT scan was described as the brain tumor with infiltrative growth, however, MRI has shown a well-demarcated tumor. The patient was admitted to the neurosurgical department for emergency surgery to treat the decompensation of intracranial hypertenzion. The comparison of tissue samples from the resected tumor with the primary thymic cancer supported by repeated morphological and immunohistochemical evaluation showed a large-cell neuroendocrine thymic tumor affecting both surgical sites. The paper points to the rare etiology of an intracerebral lesion, remarkably a long interval between primary surgery for thymic tumor and clinical manifestations of the brain metastatic lesion as well to the excellent clinical course after surgery. Czech literature gives no report of the brain metastasis of neuroendocrine thymic tumor, and only 4 similar cases have been found in the available literature.

Key words:
thymus – neuroendocrine cancer – brain metastasis


Sources

1. Chetty R, Batitang S, Govender D. Large cell neuroendocrine carcinoma of the thymus. Histopathology 1997; 3: 274-6.

2. Talton CC, Hopkins JO, Walley BD, Kincaid EH. Metastatic thymic carcinoid. Am Surg 2005; 71(7): 578-80.

3. Kong DS, Lee JI, Do HN, Park K, Suh YL. Cerebral involvement of metastatic thymic carcinoma. J Neuro Oncology 2005; 75(2): 143-7.

4. Martinez MB, Juárez AS, Alba LJ, González BM, Ordónez GA. Carcinoid tumor of the thymus gland with multiple metastases. Med Clin(Barc) 1980; 75(5): 207-10.

5. Valli M, Fabris GA, Dewar A, Chikte S, Fisher C, Corrin B et al. Atypical carcinoid tumor of the thymus. Histopathology 1994; 24(4): 371-5.

6. Yamamura K, Kubo O, Aoki N, Kagawa M. Falx metastasis of thymic carcinoma. No Shinkei Geka 1993; 21(10): 921-4.

7. Tamura Y, Kuroiwa T, Doi A, Min KY. Thymic carcinoma presenting as cranial metastasis with intradural and extracranial extension. Neurosurgery 2004; 54(1): 209-12.

8. Ahn JY, Kim NK, Oh D, Ahn HJ. Thymic carcinoma with brain metastasis mimicking meningioma. J Neuro Oncology 2002; 8(3): 193-9.

9. Al-Barbarawi M, Smith SF, Sekhon LH. Haemorrhagic brain metastasis from a thymic carcinoma. J Clin Neurosci. 2004; 11(2): 190-4.

10. Greenberg-Greenberg MS. Handbook of neurosurgery. 4th ed. Lakeland Florida: Greenberg Graphics 1997.

Labels
Paediatric neurology Neurosurgery Neurology

Article was published in

Czech and Slovak Neurology and Neurosurgery

Issue 3

2007 Issue 3

Most read in this issue

This topic is also in:


Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account