Failure of pharmacological antiepileptic treatment

Authors: V. Donáth
Authors‘ workplace: Banská Bystrica ;  II. neurologická klinika SZU FNsP F. D. Roosevelta
Published in: Cesk Slov Neurol N 2008; 71/104(2): 134-138
Category: Review Article


The treatment of epilepsy is a challenging process. Correct diagnosis, accurate classification of epileptic seizures and epilepsies, and adequate selection of the antiepileptic alone are not a guarantee of a successful treatment. There are always patients who do not meet the expectations associated with pharmacological antiepileptic treatment. Failure to attain the expected effect of treatment is most often due to the following reasons: wrong diagnosis of epilepsy, wrong drug selection for the specific type of epileptic seizure, underdosing of the antiepileptic drug, insufficient absorption of the drug or its rapid metabolism, worsening of epileptic seizures after antiepileptic treatment, pseudoseizures and real epilepsy at the same time, progression of the underlying metabolic, toxic, cancerous or degenerative brain disease, toxicity of the antiepileptic drug, non-compliance of the patient, and pharmacoresistant epilepsy.

Key words:
epilepsy - failure of treatment of epilepsy – antiepileptic treatment – epileptic seizure – pharmacoresistant epilepsy


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