Depersonalization and Derealization – Contemporary Findings

Authors: M. Raszka;  J. Praško
Authors‘ workplace: Psychiatrické centrum Praha
Published in: Cesk Slov Neurol N 2008; 71/104(3): 263-270
Category: Review Article


During depersonalization and derealization the individual experiences detachment from his own feelings, identity, body, and his mental processes seem to be unreal, far or automatic. Etiology of depersonalization and derealization is still poorly understood. In this review, a plausible model of frontolimbic disconnection is described. Next, the findings from neuroimaging, neuroendocrinological and psychopharmacological studies of subjects with depersonalization and derealization supporting or contradicting this model are discussed.

Key words:
depersonalization – derealization – functional neuroimaging – autonomic response – frontolimbic disconnection – psychotropic substances



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