Analysis of Psychological Profile and Vide o- EEG Monitoring in Sleep in Children with Developmental Dysphasi a

Authors: L. Neuschlová;  K. Štěrbová;  J. Žáčková;  V. Komárek
Authors‘ workplace: Klinika dětské neurologie UK 2. LF a FN Motol, Praha
Published in: Cesk Slov Neurol N 2009; 72/105(4): 343-349
Category: Original Paper


We analyzed data from 37 children di agnosed with developmental dysphasi a, who were referred for all‑night vide o‑EEG monitoring in order to detect epileptiform activity in sleep.

We compared the results of a psychological evalu ati on in different gro ups of child­ren, we focused on performance and verbal IQ and a vocabulary exam. Epileptiform discharges in sleep EEG were present in 12 children. Six of these children were included in an open prospective study of administering oral Di azepam for 6 to 8 months; these children were compared to six control subjects witho ut discharges in the EEG and witho ut medicati on. The aim was to verify the effect of a reducti on in epileptiform activity on langu age development.

Comparison of the initi al psychological evalu ati ons showed a tendency towards worse scores in both verbal and nonverbal skills in pati ents with epileptiform EEG activity. This trend was not evident in the yo ungest category. In the six children with epileptiform activity who participated in o ur prospective study with oral Di azepam, we fo und a marked improvement in verbal skills, demonstrated as an incre ase in verbal IQ, only in one case.

Conclusi on:
Our results do not support the hypothesis that children with developmental dysphasi a and epileptiform EEG may benefit from anti epileptic tre atment. However, o ur sample is not large eno ugh for statistical evalu ati on. Our study may serve as a valu able so urce of informati on for further prospective studi es in pati ents with developmental dysphasi a.

Key words:
dysphasia – electroencephalography


1. Dlo uhá O. Opožděný vývoj řeči a vývojové poruchy řeči. Vox pedi atri ae 2004; 9: 25– 27.

2. Conti‑Ramsden G, Botting N, Faragher B. Psycholinguistic markers for specific langu age impairment (SLI). J Child Psychol Psychi atry 2001; 42(6): 741– 748.

3. Stark RE, Tallal P. Selecti on of children with specific langu age deficits. J Speech He ar Disord 1981; 46: 114– 122.

4. Cole KN, Dale PS, Mills PE. Stability of the intelligence quoti ent- langu age quoti ent relati on: is discrepancy modeling based on a myth? Am J Ment Retard 1992; 97(2): 131– 143.

5. Swisher L, Plante E, Lowell. Nonlinguistic deficits of langu age- impaired children complicate the interpretati on of their nonverbal IQ scores. Lang Speech He ar Serv Sch 1994; 25: 235– 240.

6. Aram DM, Morris R. Clinical and rese arch congruence in identifying children with specific langu age impairment, J Speech He ar Res 1993; 36(3): 580– 591.

7. Cole K, Mills PE, Kelley D. Agreement of assessment profiles used in Cognitive Referencing. Lang Speech He ar Serv Sch 1994; 25: 25– 31.

8. Bishop DV. Is Specific Langu age Impairment a Valid Di agnostic Category? Genetic and Psycholinguistic Evidence. Philos Trans R Soc Lond B Bi ol Sci 1994; 346(1315): 105– 111.

9. Dlo uha O, Nevsimalova S. EEG changes and epilepsy in developmental dysphasi a. Suppl Clin Ne urophysi ol 2000; 53: 271– 274.

10. Škodová E, Michek F, Moravcová M. Hodnocení fonematického sluchu u předškolních dětí. Testová bateri e. Ostrava: Re ali a 1995.

11. Cavazuti GB, Cappella L, Nalin A. Longitudinal study of epileptiform EEG patterns in normal children. Epilepsi a 1980; 21(1): 43– 55.

12. Eeg- Olofsson O, Petersén I, Selldén U. The development of the electroencephalogram in normal children from the age of 1 thro ugh 15 ye ars. Paroxysmal activity. Ne uropadi atri e 1971; 2(4): 375– 404.

13. Okubo Y, Matsuura M, Asai T, Asai K, Kato M, Kojima T et al. Epileptiform EEG Discharges in He althy Children: Prevalence, Emoti onal and Behavi oral Correlates, and Genetics Influences. Epilepsi a 1994; 35(4): 832– 841.

14. Picard A, Chéli o ut- Hera ut F, Bo uskrao ui M, Lemo ine, M,Lacert P, Delattre J. Sleep EEG and developmental dysphasi a. Dev Med Child Ne urol 1998; 40(9): 595– 599.

15. Chéli o ut- Héra ut F, Picard A, Bo uskrao ui M, Lacert P.Anomali es EEG, modificati ons du sommeil et dysphasi es de développement. Ne urophysi ol Clin 1999; 29(3): 277– 289.

16. Duvelleroy- Hommet C, Billard C, Lucas B, Gillet P, Barthes MA, Santini JJ et al. Sleep EEG and Developmental Dysphasi a: Lack of a Consistent Relati onship with Paroxysmal EEG Activity During Sleep. Ne uropedi atrics 1995; 26(1): 14– 18.

17. Dlo uhá O. Vývojové poruchy řeči. Praha: Univerzita Karlova 2003: 98– 100.

18. Tuchman RF, Rapin I, Shinnar S. Autistic and Dysphasic Children I: Clinical Characteristic. Pedi atrics 1991; 88: 1211– 1218.

19. Tuchman FR, Rapin I, Shinnar S. Autistic and Dysphasic Children. II: Epilepsy. Pedi atrics 1991; 88(3): 1219– 1225.

20. Venkateswaran S, Shevell M. The Case against Ro utine Electroenephalography in Specific Langu age Impairment. Pedi atrics 2008; 122(4): 911– 916.

21. Hrdicka M, Komarek V, Propper L, Kulisek R, Zumrova A, Faladova L et al. Not EEG abnormaliti es but epilepsy is associ ated with a utistic regressi on and mental functi oning in childho od a utism. Eur Child Adolesc Psychi atry 2004; 13(4): 209– 213.

22. Scabar A, Devescovi R, Blason L, Bravar L, Carro ozzi M.Comorbidity of DCD and SLI: significance of epileptiform activity during sleep. Child Care He alth Dev 2006; 32(6), 733– 739.

23. Holtmann M, Becker K, Kentner- Figura B, Schmidt MH. Incre ased Frequency of Rolandic Spikes in ADHD Children. Epilepsi a 2003; 44(9): 1241– 1244.

24. Do ose H, Brigger- He uer B, Ne uba uer B. Children with Focal Sharp Waves: Clinical and Genetic Aspects. Epilepsi a 1997; 38(7): 788– 796.

25. Landa u WM, Kleffner FR. Syndrome of Acquired Aphasi a with Convulsive Disorder in Children. Ne urology 1957; 7(8): 523– 530.

26. Pe arl PL, Carrazana EJ, Holmes GL. The Landa u- Kleffner Syndrome. Epilepsy Curr 2001; 1(2): 39– 45.

27. Roger J, Bure a u M, Dravet Ch, Genton P, Tassinari CA, Wolf O. Epileptic Syndromes in Infancy, Childho od and Adolescence. 4th ed. London: John Libbey 2005: 295– 314.

28. Ne uschlová L, Sterbová K, Zacková J, Komárek V.Epileptiform activity in children with developmental dysphasi a: qu antificati on of discharges in overnight sleep vide o‑EEG. Epileptic Disord 2007 (9 Suppl 1): S28– 35.

29. Go orhuis- Bro uwer SM, Knijff WA. Efficacy of speech therapy in children with langu age disorders: specific langu age impairment compared with langu age impairment in comorbidity with cognitive delay. Int J Pedi atr Otorhinolaryngol 2002; 63(2): 129– 136.

30. Krassowski E, Plante E. IQ vari ability in children with SLI: implicati ons for use of cognitive referencing in determining SLI. J Commun Disord 1997; 30(1): 1– 8.

31. Botting N. Non- verbal cognitive development and langu age impairment, J Child Psychol Psychi atry 2005; 46(3): 317– 326.

32. Kossoff EH, Los JG, Bo atman DF. A pilot study transiti oning children onto levetiracetam monotherapy to improve langu age dysfuncti on associ ated with benign rolandic epilepsy. Epilepsy Behav 2007; 11(4): 514– 517.

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