Neuro-endocrine Dysfunction in Children and Adolescents after Brain Injury

Czech version

Authors: D. Aleksijević ¹; J. Zapletalová ¹; V. Smolka ¹; E. Klásková ¹; J. Wiedermann ¹; D. Krahulík ² ; J. Vaverka ²; Z. Fryšák ³
Authors‘ workplace: LF UP a FN Olomouc Dětská klinika ¹; LF UP a FN Olomouc Neurochirurgická klinika ²; LF UP a FN Olomouc III. interní klinika ³
Published in: Cesk Slov Neurol N 2010; 73/106(4): 409-414
Category: Short Communication

Overview

Background:
Neuro-endocrine dysfunction after traumatic brain injury is found in 23–60% of adult patients. Objectives: To evaluate growth, pubertal development and endocrine function in children and adolescents after traumatic brain injury. Patients and methods: We evaluated growth, pubertal development and bone age in 30 patients (18 boys) after traumatic brain injury. They underwent standard endocrine tests –⁠ thyreotropin, free thyroxin, insulin-like growth factor, prolactin, morning cortisol, gonadotropins, testosterone (in boys) and oestradiol (in girls). Dynamics tests were performed in patients with abnormalities revealed by clinical examination and/or laboratory results. Median patient age at the time of brain trauma was 9.7 (0.4–14.8) years; 75% of patients were prepubertal. Their range of Glasgow Coma Scale (GCS) was 3–12 (11 of these

Key words:
traumatic brain injury –⁠ children –⁠ post-traumatic hormonal disorder –⁠ growth hormone deficiency –⁠ precocious puberty –⁠ risk factors

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