Unilateral Basal Ganglia Hypoplasia in a Patient with Epilepsy – a Case Report

Authors: M. Kaiserová 1;  E. Čecháková 2;  R. Mařák 3;  M. Šmídová 4;  K. Farníková 1;  P. Kaňovský 1
Authors‘ workplace: FN Olomouc Centrum pro diagnostiku a léčbu neurodegenerativních onemocnění, Neurologická klinika LF UP v Olomouci 1;  FN Olomouc Radiologická klinika LF UP v Olomouci 2;  FN Olomouc Centrum pro epilepsie, Neurologická klinika LF UP v Olomouci 3;  FN Olomouc Oddělení klinické psychologie 4
Published in: Cesk Slov Neurol N 2010; 73/106(4): 430-433
Category: Case Report


The occurrence of a larger basal ganglia lesion without motor disorder, behavioural abnormality or disturbance of speech is exceedingly rare; only one case appears in the relevant literature. We report a second case of a patient with unilateral hypoplasia of the basal ganglia without motor impairment, who suffered from temporal lobe epilepsy. We hypothesize damage to the right basal nuclei at an early stage in the development of the brain. Neuronal plasticity at this stage of development might have been responsible for the normal motor function acquired. We also hypothesize that the basal ganglia have a weak inhibitory effect on the further spread of epileptic activity, which might have helped facilitate the development of temporal lobe epilepsy.

Key words:
basal ganglia – motor function – temporal lobe epilepsy


1. Bhatia KP, Marsden CD. The behavioural and motor consequences of focal lesions of the basal ganglia in man. Brain 1994; 117 (Pt 4): 859–876.

2. DeLong GR. Mid-gestation right basal ganglia lesion: clinical observations in two children. Neurology 2002; 59(1): 54–58.

3. Mercuri E, Barnett A, Rutherford M, Guzzetta A, Haataja L, Cioni G et al., Neonatal cerebral infarction and neuromotor outcome at school age. Pediatrics 2004; 113 (1): 95–100.

4. Kellinghaus C, Montgomery E, Neme S, Ruggieri P, Lüders HO. Unilateral absence of the basal ganglia plus epilepsy without motor symptoms. Neurology 2003; 60(5): 870–873.

5. Hazrati LN, Parent A. Contralateral pallidothalamic and pallidotegmental projections in primates: an anterograde and retrograde labeling study. Brain Res 1991; 567(2): 212–223.

6. Christensen J, Sørensen JC, Ostergaard K, Zimmer J. Early postnatal development of the rat corticostriatal pathway: an anterograde axonal tracing study using biocytin pellets. Anat Embryol (Berl) 1999; 200(1): 73–80.

7. Tasch E, Cendes F, Li LM, Dubeau F, Andermann F, Arnold DL. Neuroimaging evidence of progressive neuronal loss and dysfunction in tempoval lobe epilepsy. Ann Neurol 1999; 45(5): 568–576

8. Seidenberg M, Kelly KG, Parrish J, Geary E, Dow C, Rutecki P et al. Ipsilateral and contralateral MRI Volumetric Abnormalities in chronic unilateral temporal lobe epilepsy and thein clinical correlates. Epilepsia 2005; 46(3): 420–430.

9. Pulsipher DT, Seidenberg M, Morton JJ, Geary E, Parrish J, Hermann B. MRI volume loss of subcortical structures in unilateral temporal lobe epilepsy. Epilepsy Behav 2007; 11(3): 442–449.

10. Rektor I, Kuba R, Brázdil M. Interictal and Ictal EEG Activity in the Basal Ganglia: An SEEG Study in Patients with Temporal Lobe Epilepsy. Epilepsia 2002; 43(3): 253–262.

11. Dematteis M, Kahane P, Vercueil L, Depaulis A. MRI evidence for the involvement of basal ganglia in epileptic seizures: an hypothesis. Epileptic Disord 2003; 5(3): 161–164.

Paediatric neurology Neurosurgery Neurology

Article was published in

Czech and Slovak Neurology and Neurosurgery

Issue 4

2010 Issue 4

Most read in this issue

This topic is also in:

Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account