Hypothalamo-Pituitary Dysfunction Following Traumatic Brain Injury and Spontaneous Subarachnoid Haemorrhage

Authors: M. Kosák;  V. Hána
Authors‘ workplace: III. interní klinika 1. LF UK a VFN v Praze
Published in: Cesk Slov Neurol N 2011; 74/107(3): 286-291
Category: Review Article


The authors provide a review of observed hypothalamo-pituitary dysfunction following traumatic brain injury (TBI) and spontaneous subarachnoid haemorrhage (SAH) based on studies published in peer-reviewed journals. In most of the studies published in the last ten years, neuro-endocrine dysfunction after TBI and SAH appeared more often than previously. Impaired secretion of anterior pituitary hormones was diagnosed after TBI in up to 28.9% of cases and after SAH in up to 56.8%. Diabetes insipidus centralis was observed after TBI in acute phase in 26% and in chronic phase in 6.9%. Some recent studies did not confirm such high frequency. Currently we cannot predict the potential risk of neuro-endocrine sequelae of TBI in the individual patient. Although guidelines for endocrine evaluation of patients after TBI and SAH have been published, it appears that they have not yet become part of routine practice.

Key words:
hypothalamo-pituitary dysfunction – hypopituitarism – diabetes insipidus centralis – traumatic brain injury – subarachnoid haemorrhage


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