The Impact of Surgical Treatment on Prognosis for Adult Patients Harbouring Supratentorial Low-Grade Glioma

Authors: A. Šteňo 1;  V. Belan 2;  P. Kalina 3;  M. Fabian 2;  J. Šteňo 1
Authors‘ workplace: LF UK a UN Bratislava Neurochirurgická klinika 1;  LF UK a UN Bratislava Rádiodiagnostická klinika 2;  LF UK a UN Bratislava II. Neurologická klinika 3
Published in: Cesk Slov Neurol N 2011; 74/107(3): 273-278
Category: Review Article


Adult supratentorial low-grade glioma (grade II. glioma) tends to malignant dedifferentiation and fatal outcome. In the absence of any prospective randomized study, the role of surgery in low-grade glioma treatment has been discussed for years. However, ethical considerations render comparative study of the matter very difficult to organise. Retrospective studies suffer from intrinsic selection bias, and the authors of early papers were unable to record reliable criteria for assessment of the extent of resection – operative reports and computer tomography. The result of such works were not consistent, so the role of surgical treatment was, and still is, controversial. However, several recent retrospective studies have assessed the extent of resection via reliable criteria – T2 and fluid-attenuated inversion recovery (FLAIR) magnetic resonance sequences. These verified improved prognosis after extensive low-grade glioma resection. Therapeutic strategy must be based on the best evidence available, so nowadays maximal safe surgical resection is recommended as the treatment of choice.

Key words:
low-grade glioma – surgical treatment – prognosis


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