Treatment Adherence in Patients with Schizophrenia

Authors: L. Ustohalihash2 1,2 1,2
Authors‘ workplace: CEITEC MU, Brno 1;  Psychiatrická klinika LF MU a FN Brno 2
Published in: Cesk Slov Neurol N 2012; 75/108(3): 391-394
Category: Treatment News


Treatment nonadherence is quite frequent in patients with schizophrenia and represents a se­rious problem. It is, therefore, necessary to monitor adherence and to influence it in a po­­sitive way. Measurement of antipsychotic plasma levels can be done quite precisely. In addition, optimal therapeutic plasma levels of a number of antipsychotic drugs are known. Consequently, measurement of antipsychotic plasma levels is considered to be the most suitable method for adherence monitoring. Of the various factors that contribute to nonadherence, we are able to especially influence those that are associated with physicians and the treatment. These factors include treatment efficacy without unpleasant or potentially dangerous side-effects, monotherapy or, if necessary, combinations of antipsychotics or other drugs based on thorough knowledge of their pharmacokinetics. Patient insight represents another important factor; we should strive to develop patient insights and thus establish the basis for a therapeutic partnership.

Key words:
adherence – schizophrenia – antipsychotics


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