The Use of Optical Coherence Tomography in Multiple Sclerosis


Authors: V. Matušková 1;  J. Lízrová Preiningerová 2;  D. Vysloužilová 1;  M. Michalec 1;  Z. Kasl 3;  E. Vlková 1
Authors‘ workplace: Oční klinika LF MU a FN Brno 1;  Neurologická klinika a Centrum klinických neurověd, 1. LF UK a VFN v Praze 2;  Oční klinika LF UK a FN Plzeň 3
Published in: Cesk Slov Neurol N 2016; 79/112(1): 33-40
Category: Review Article
doi: https://doi.org/10.14735/amcsnn201633

Overview

Optical coherence tomography is fast, non-invasive and reproducible imaging technique that provides detailed measurements of retinal structures. Retinal pathology in multiple sclerosis (MS) includes consequences of optic neuritis as well as diffuse degenerative changes. Thinning of retinal nerve fiber layer, decrease in total macular volume and loss of retinal ganglion cell layer correlate with visual acuity, brain atrophy measures and cognitive changes. Anterior visual pathway became a model of neuroaxonal injury in MS and is used to test neuroprotective effects of new therapies. The paper provides an overview of the physics of optical coherence tomography and its application in MS.

Key words:
optical coherence tomography – multiple sclerosis – retinal nerve fibre layer – total macular volume

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.


Sources

1. Havrdová E. Roztroušená skleróza. 1. vyd. Praha: Mladá Fronta 2013.

2. The Optic Neuritis Study Group. Visual function5 years after optic neuritis: experience of the OpticNeuritis Treatment Trial. Arch Ophthalmol 1997; 115(12): 1545– 1552.

3. Ikuta F, Zim­merman HM. Distribution of plaques in seventy autopsy cases of multiple sclerosis in the United States. Neurology 1976; 26(2): 26– 28.

4. Di Maggio G, Santangelo R, Guer­rieri S, Bianco M, Fer­rari L, Medaglini S et al. Optical coherence tomography and visual evoked potentials: which is more sensitive in multiple sclerosis? Mult Scler 2014; 20(10): 1342– 1347. doi: 10.1177/ 1352458514524293.

5. Abràmoff MD, Garvin MK, Sonka M. Retinal imag­ing and image analysis. IEEE Trans Med Imag­ing 2010; 3: 169– 208.

6. Scoles D, Gray D, Hunter J, Wolfe R, Gee B, Geng Y et al. In vivo imag­ing of retinal nerve fiber layer vasculature: imag­ing-histology comparison. BMC Ophthalmology 2009; 9: 1– 9. doi: 10.1186/ 1471-2415-13-76.

7. Drexler W, Fujimoto JG. State-of-the-art retinal optical coherence tomography. Prog Retin Eye Res 2008; 27(1): 45– 88.

8. Tewarie P, Balk L, Costel­lo F, Green A, Martin R, Schippl­ing S et al. The OSCAR-IB consensus criteria for retinal OCT quality as­ses­sment. PLoS One 2012; 7(4): e34823. doi: 10.1371/ journal.pone.0034823.

9. Schippl­ing S, Balk LJ, Costel­lo F, Albrecht P, Balcer L, Calabresi PA et al. Quality control for retinal OCT in multiple sclerosis: validation of the OSCAR-IB criteria. Mult Scler 2015; 21(2): 163– 170. doi: 10.1177/ 1352458514538110.

10. Patel NB, Garcia B, Harwerth RS. Influence of anterior segment power on the scan path and RNFL thickness us­ing SD-OCT. Invest Ophthalmol Vis Sci 2012; 53(9): 5788– 5798. doi: 10.1167/ iovs.12-9937.

11. Faghihi H, Hajizadeh F, Hashemi H, Khabazkhoob M. Agreement of two dif­ferent spectral domain optical coherence tomography instruments for retinal nerve fiber layer measurements. J Ophthalmic Vis Res 2014; 9(1): 31– 37.

12. Sakata LM, Deleon-Ortega J, Sakata V, Girkin CA. Optical coherence tomography of the retina and optic nerve –  a review. Clin Experiment Ophthalmol 2009; 37(1): 90– 99. doi: 10.1111/ j.1442-9071.2009.02015.x.

13. Lucchinetti CF, Bruck W, Rodriguez M, Las­smann H. Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis. Brain Pathol 1996; 6(3): 259– 274.

14. Trapp BD, Bo L, Mork S, Chang A. Pathogenesis of tis­sue injury in MS lesions. J Neuroim­munol 1999; 98(1): 49– 56.

15. Balk LJ, Petzold A. Cur­rent and future potential of retinal optical coherence tomography in multiple sclerosis with and without optic neuritis. Neurodegener Dis Manag 2014; 4(2): 165– 176. doi: 10.2217/ nmt.14.10.

16. Parisi V, Man­ni G, Spadaro M, Colacino G, Restuccia R, Marchi S et al. Cor­relation between morphological and functional retinal impairment in multiple sclerosis patients. Invest Ophthalmol Vis Sci 1999; 40(11): 2520– 2527.

17. Petzold A, de Boer JF, Schippl­ing S, Vermersch P, Kardon R, Green A et al. Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis. Lancet Neurol 2010; 9(9): 921– 932. doi: 10.1016/ S1474-4422(10)70168-X.

18. Costel­lo F, Coupland S, Hodge W, Lorel­lo GR, Koroluk J, Pan YI et al. Quantify­ing axonal loss after optic neuritis with optical coherence tomography. Ann Neurol 2006; 59(6): 963–969.

19. Costel­lo F, Hodge W, Pan YI, Eggenberger E, Coupland S, Kardon RH. Track­ing retinal nerve fiber layer loss after optic neuritis: a prospective study us­ing optical coherence tomography. Mult Scler 2008; 14(7): 893– 905. doi: 10.1177/ 1352458508091367.

20. Huang-Link YM, Al-Hawasi A, Lindeham­mar H. Acute optic neuritis: retinal ganglion cell loss precedes retinal nerve fiber thin­ning. Neurol Sci 2015; 36(4): 617– 620. doi: 10.1007/ s10072-014-1982-3.

21. Michalec M, Praksová P, Hladíková M, Matušková V, Vlková E, Štourač P et al. Pozorovanie hrúbky vrstvy nervových vlákien sietnice u pa­cientov so sklerózou multiplex pomocou optickej koherentnej tomografie. Cesk Slov Neurol N 2016; 78/ 112(1): 41–50.

22. Kupersmith MJ, Garvin MK, Wang JK, Durbin M, Kardon R. Retinal ganglion cell layer thin­n­ing within one month of presentation for optic neuritis. Mult Scler 2015: pii: 1352458515598020.

23. Green AJ, Cree BA. Distinctive retinal nerve fibre layer and vascular changes in neuromyelitis optica fol­low­ing optic neuritis. J Neurol Neurosurg Psychiatry 2009; 80(9): 1002– 1005. doi: 10.1136/ jn­np.2008.166207.

24. Syc SB, Saidha S, Newsome SD, Ratchford JN, Levy M, Ford E et al. Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis. Brain 2012; 135(2): 521– 533. doi: 10.1093/ brain/ awr264.

25. Watson GM, Keltner JL, Chin EK, Harvey D, Nguyen A, Park S­S. Comparison of retinal nerve fiber layer and central macular thickness measurements among five dif­ferent optical coherence tomography instruments in patients with multiple sclerosis and optic neuritis. J Neuroophthalmol 2011; 31(2): 110– 116. doi: 10.1097/ WNO.0b013e3181facbbd.

26. Shindler KS, Ventura E, Dutt M, Rostami A. Inflam­matory demyelination induces axonal injury and retinal ganglion cell apoptosis in experimental optic neuritis. Exp Eye Res 2008; 87(3): 208– 213. doi: 10.1016/ j.exer.2008.05.017.

27. Saidha S, Syc SB, Ibrahim MA, Eckstein C, Warner CV, Far­rell SK et al. Primary retinal pathology in multiple sclerosis as detected by optical coherence tomography. Brain 2011; 134(2): 518– 533. doi: 10.1093/ brain/ awq346.

28. Trip SA, Schlottmann PG, Jones SJ, Li WY, Garway-Heath DF, Thompson AJ et al. Optic nerve atrophy and retinal nerve fibre layer thin­n­ing fol­low­ing optic neuritis: evidence that axonal loss is a substrate of MRI-detected atrophy. Neuroimage 2006; 31(1): 286– 293.

29. Costel­lo F, Hodge W, Pan YI, Eggenberger E, Freedman MS. Us­ing retinal architecture to help characterize multiple sclerosis patients. Can J Ophthalmol 2010; 45(5): 520– 526. doi: 10.3129/ i10-063.

30. Gelfand JM, Goodin DS, Boscardin WJ, Nolan R, Cuneo A, Green AJ. Retinal axonal loss begins early in the course of multiple sclerosis and is similar between progres­sive phenotypes. PLoS One 2012; 7(5): e36847. doi: 10.1371/ journal.pone.0036847.

31. Costel­lo F, Hodge W, Pan YI, Freedman M, DeMeulemeester C. Dif­ferences in retinal nerve fiber layer atrophy between multiple sclerosis subtypes. J Neurol Sci 2009; 281(1– 2): 74– 79. doi: 10.1016/ j.jns.2009.02.354.

32. Henderson AP, Trip SA, Schlottmann PG, Altmann DR, Garway-Heath DF, Plant GT et al. An investigation of the retinal nerve fibre layer in progres­sive multiple sclerosis us­ing optical coherence tomography. Brain 2008; 131(1): 277– 287.

33. Dorr J, Wernecke KD, Bock M, Gaede G, Wuerfel JT, Pfuel­ler CF et al. As­sociation of retinal and macular damage with brain atrophy in multiple sclerosis. PLoS One 2011; 6(4): e18132. doi: 10.1371/ journal.pone.0018132.

34. Greenberg BM, Frohman E. Optical coherence tomography as a potential readout in clinical trials. Ther Adv Neurol Disord 2010; 3(3): 153– 160. doi: 10.1177/ 1756285610368890.

35. Frohman EM, Costel­lo F, Stuve O, Calabresi P, Mil­ler DH, Hickman SJ et al. Model­ing axonal degeneration within the anterior visual system: implications for demonstrat­ing neuroprotection in multiple sclerosis. Arch Neurol 2008; 65(1): 26– 35. doi: 10.1001/ archneurol.2007.10.

Labels
Paediatric neurology Neurosurgery Neurology
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account