Cognitive Functions in Low-grade Glioma Patients –  a Systematic Review

Authors: K. Schönová 1;  S. Weissenberger 2;  M. Preiss 3;  P. Harsa 2
Authors‘ workplace: Dětská psychiatrická nemocnice Louny 1;  Psychiatrická klinika 1. LF UK a VFN v Praze 2;  Národní ústav duševního zdraví, Klecany 3
Published in: Cesk Slov Neurol N 2017; 80/113(4): 396-399
Category: Review Article
doi: 10.14735/amcsnn2017396


This review summarises the topic of cognitive functions in patients with low-grade gliomas. Gliomas and their treatment have a negative effect on the cognitive functions of these patients. Cognitive functions in patients with low-grade glioma influence also the quality of their life which correlates with life expectancy. This is a relatively new area of research, but the increasing number of published articles shows its relevance. The aim of this review is to introduce and emphasise this topic and contribute to the development of the quality of professional care for patients with low-grade gliomas.

Key words:
low-grade gliomas – cognitive functions – rehabilitation of cognitive functions – quality of life

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.


1. Klener P, Abrahámová J, Fait V, et al. Klinická onkologie. Praha: Galén 2000.

2. Šlampa P. Gliomy: současná dia­gnostika a léčba. Praha: Maxdorf 2013.

3. Haberland C. Clinical neuropathology: text and color atlas. New York: Demos Medical Publish­ing 2007.

4. Singh D, Kapoor A, Khadda S, et al. Psychotic manifestations as an initial presentation in glioma: two case reports and review of literature. Neuropsychiatria i Neuropsychologia 2013;9(1):1– 3.

5. Youland RS, Schomas DA, Brown PD, et al. Changes in presentation, treatment, and outcomes of adult low-grade gliomas over the past fifty years. Neuro Oncol 2013;15(8):1102– 10. doi: 10.1093/ neuonc/ not080.

6. Kulišťák P, et al. Případové studie z klinické neuropsychologie. Praha: Karolinum 2011.

7. Klein M, Heimans JJ, Aaronson NK, et al. Ef­fect of radiotherapy and other treatment-related factors on mid-term to long-term cognitive sequelae in low-grade gliomas: a comparative study. Lancet 2002;360(9343):1361– 8.

8. Påhlson A, Ek L, Ahlström G, et al. Pitfal­ls in the as­ses­s­ment of disability in individuals with low-grade gliomas. J Neurooncol 2003;65(2):149– 58.

9. Ek L, Almkvist O, Kristof­fersen Wiberg M, et al. Early cognitive impairment in a subset of patients with presumed low-grade glioma. Neurocase 2010;16(6):503– 11. doi: 10.1080/ 13554791003730634.

10. Lilja AM, Portin RI, Hämäläinen PI, et al. Short-term ef­fects of radiotherapy on attention and memory performances in patients with brain tumors. Cancer 2001;91(12):2361– 8.

11. Cor­rea DD, DeAngelis LM, Shi W, et al. Cognitive functions in low-grade gliomas: disease and treatment ef­fects. J Neurooncol 2007;81(2):175– 84.

12. Noll KR, Sul­laway C, Ziu M, et al. Relationships between tumor grade and neurocognitive function­ing in patients with glioma of the left temporal lobe prior to surgical resection. Neuro-Oncol 2015;17(4):580– 7. doi: 10.1093/ neuonc/ nou233.

13. Douw L, Klein M, Fagel S, et al. Cognitive and radiological ef­fects of radiotherapy in patients with low-grade glioma: long-term fol­low-up. Lancet Neurol 2009;8(9):810– 8. doi: 10.1016/ S1474-4422(09)70204-2.

14. Gehr­ing K, Aaronson N, Gundy C, et al. M. Predictors of Neuropsychological Improvement Fol­low­ing Cognitive Rehabilitation in Patients with Gliomas. J Int Neuro-psychol Soc 2011;17(2):256– 66. doi: 10.1017/ S135561771000 1530.

15. MuY, Huang L, Li S, et al. Work­ing memory and the identification of facial expres­sion in patients with left frontal glioma. Neuro Oncol 2012;14(4):81– 9. doi: 10.1093/ neuonc/ nos215.

16. Reijneveld J, Sitskoorn M, Klein M, et al. Cognitive status and quality of life in patients with suspected versus proven low-grade gliomas. Neurology 2001;56(5):618– 23.

17. Johnson DR, Sawyer AM, Meyers CA, et al. Early measures of cognitive function predict survival in patients with newly dia­gnosed glioblastoma. Neuro Oncol 2012;14(6):808– 16. doi: 10.1093/ neuonc/ nos082.

18. Meyers CA, Hess KR. Multifaceted end points in brain tumor clinical trials: cognitive deterioration precedes MRI progres­sion. Neuro Oncol 2003;5(2):89– 95.

19. Tucha O, Smely C, Preier M, et al. Cognitive deficits before treatment among patients with brain tumors: methodological is­sues and results. Neurosurgery 2000;47(2):69– 90.

20. Ek L, Smits A, Påhlson A, et al. Analysis of Cognitive Dysfunction in Patients with Low-Grade Glioma. J Clin Psychol Med Settings 2005;12(2):165– 73.

21. Noll KR, Ziu M, Weinberg JS, et al. Neurocognitive function­ing in patients with glioma of the left and right temporal lobes. J Neurooncol 2016;128(2):323– 31. doi: 10.1007/ s11060-016-2114-0.

22. Klein M, Engelberts NH, van der Ploeg HM, et al. Epilepsy in low-grade gliomas: The impact on cognitive function and quality of life. An­n Neurol 2003;54(4):514– 20.

23. Plaza M, Capel­le L, Maigret G, et al. Strengths and weaknes­ses of multimodal proces­s­ing in a group of adults with gliomas. Neurocase 2013;19(3):302– 12. doi: 10.1080/ 13554794.2012.667128.

24. Boone M, Rous­sel M, Chauf­fert B, et al. Prevalence and profile of cognitive impairment in adult glioma: a sensitivity analysis. J Neurooncol 2016;129(1):123– 30. doi: 10.1007/ s11060-016-2152-7.

25. Duf­fau, H, Capel­le, L, Denvil, D, et al. Usefulness of intraoperative electrical subcortical mapp­ing dur­ing surgery for low-grade gliomas located within eloquent brain regions: functional results in a consecutive series of 103 patients. J Neurosurg 2003;98(4):764– 78.

26. Raysi DS, Mariano M, Mazza M, et al. Cognitive deficits in patients with low and high-grade gliomas. J Neurosurg Sci 2013;57(3):259– 66.

27. Talacchi A, Santini B, Savazzi S, et al. Cognitive ef­fects of tumour and surgical treatment in glioma patients. J Neurooncol 2011;103(3):541– 9. doi: 10.1007/ s11060-010-0417-0.

28. Sanai N, Mirzadeh Z, Berger MS. Functional outcome after language mapp­ing for glioma resection. N Engl J Med 2008;358(1):18– 27. doi: 10.1056/ NEJMoa067819.

29. Satoer D, Vork J, Visch-Brink E, et al. Cognitive function­ing early after surgery of gliomas in eloquent areas: clinical article. J Neurosurg 2012;117(5):831– 8. doi: 10.3171/ 2012.7.JNS12263.

30. Teixidor P, Gatignol P, Leroy M, et al. As­ses­sment of verbal work­ing memory before and after surgery for low-grade glioma. J Neurooncol 2007;81(3):305– 13.

31. Chan MD. Recent technical advances and indications for radiation therapy in low-grade glioma. Semin Radiat Oncol 2015;25(3):189– 96. doi: 10.1016/ j.semradonc.2015.02.001.

32. Brown PD, Jaeckle K, Bal­lman KV et al. Ef­fect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1 to 3 brain metastases: a randomized clinical trial. JAMA 2016;316(4):401– 9. doi: 10.1001/ jama.2016.9839.

33. Laack, NN, Brown, PD, Ivnik, RJ et al. Cognitive function after radiotherapy for supratentorial low-grade glioma: a North Central Cancer Treatment Group prospective study. Int J Radiat Oncol Biol Phys 2005;63(4):1175– 83.

34. Brown PD, Buckner JC, O’Fal­lon JR, et al. Ef­fects of radiotherapy on cognitive function in patients with low-grade glioma measured by the folstein mini-mental state examination. J Clin Oncol 2003;21(13):2519– 24.

35. Ortinski P, Meador KJ. Cognitive side ef­fects of anti­-epileptic drugs. Epilepsy Behav 2004;5:60– 5.

36. Edvards­son T, Ahlström G. Il­lnes­s-related problems and cop­ing among persons with low-grade glioma. Psychooncology 2005;14(9):728– 37.

37. Kulišťák P. Neuropsychologie. Praha: Portál 2003.

38. Elgamal S, McKin­non M, Ramakrisnan K, et al. Succes­s­­-ful computer-as­sisted cognitive remediation therapy in patients with unipolar depres­sion: a proof of principle study. Psychol Med 2007;37(9):1229– 38.

39. Peretz C, Korczyn A, Shatil E, et al. Computer-based, personalized cognitive train­ing versus clas­sical computer games: a randomized double-blind prospective trial of cognitive stimulation. Neuroepidemiology 2011;36(2):91– 9. doi: 10.1159/ 000323950.

40. Alvarez LM, Sotres JFC, León SO, et al. Computer program in the treatment for major depres­sion and cognitive impairment in university students. Comput Human Behav 2008;24(3):816– 26.

41. Anders­son G, Cuijpers P. Internet-based and other computerized psychological treatments for adult depres­sion: a meta-analysis. Cogn Behav Ther 2009;38(4): 196– 205. doi: 10.1080/ 16506070903318960.

42. Čermáková R, Rodriguez M, Preiss M. Rehabilitace kognitivních funkcí on-line: možnosti programu cognifit. Psychiatrie 2010;14(3):76– 9.

43. Chmelařová D, Ambler Z, Dostál M, et al. Rehabilitace kognitivních funkcí u pa­cientů s roztroušenou sklerózou. Cesk Slov Neurol N 2014;77/ 110(6):677– 83.

44. Boele FW, Leeuw IMV, Cuijpers P, et al. Internet-based guided self-help for glioma patients with depres­sive symp­toms: design of a randomized control­led trial. BMC Neurol 2014;14:81. doi: 10.1186/ 1471-2377-14-81.

45. Boul­laya V, Plazab M, Per­raulta A, et al. Atypical cros­smodal emotional integration in patients with gliomas. Brain Cogn 2014;1(92):92– 100. doi: 10.1016/ j.bandc.2014.10.003.

46. Hahn C, Dunn R, Logue P, et al. Prospective study of neuropsychologic test­ing and quality-of-life as­ses­sment of adults with primary malignant brain tumors. Int J Radiat Oncol Biol Phys 2003;55(4):992– 9.

47. Pringle A, Taylor R, Whittle I. Anxiety and depres­sion in patients with an intracranial neoplasm efore and after tumour surgery. Br J Neurosurg 1999;13(1):46– 51.

48. Mainio A, Tuunanen S, Hakko H, et al. Decreased quality of life and depres­sion as predictors for shorter survival among patients with low-grade gliomas: a fol­low-up from 1990 to 2003. Eur Arch Psychiatry Clin Neurosci 2006;256(8):516– 21.

49. Miotto EC, Junior AS, Silva CC, et al. Cognitive impairments in patients with low grade gliomas and high grade gliomas. Arq Neuropsiquiatr 2011;69(4):596–601.

Paediatric neurology Neurosurgery Neurology

Article was published in

Czech and Slovak Neurology and Neurosurgery

Issue 4

2017 Issue 4

Most read in this issue

This topic is also in:

Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account