Two Cases of CNS Atypical Theratoid Rhabdoid Tumor and Review of Literature

Authors: H. Zítek 1;  D. Sumerauer 2;  J. Zámečník 3;  P. Vachata 1;  M. Sameš 1;  A. Puchmajerová 4
Authors‘ workplace: Neurochirugická klinika UJEP a Masarykova nemocnice v Ústí nad Labem, o. z, Krajská zdravotní, a. s., Ústí nad Labem 1;  Klinika dětské hematologie a onkologie 2. LF UK a FN Motol, Praha 2;  Ústav patologie a molekulární medicíny, 2. LF UK a FN Motol, Praha 3;  Ústav biologie a lékařské genetiky, 2. LF UK a FN Motol, Praha 4
Published in: Cesk Slov Neurol N 2017; 80/113(5): 605-607
Category: Letter to Editor


The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.


1. Buscariol­lo DL, Park HS, Roberts KB, et al. Surviv­­al outcomes in atypical teratoid rhabdoid tumor for patients undergo­­ing radiother­apy in a Surveil­lance, Epidemiology, and End Results analysis. Cancer 2012;118(17):4212– 19. doi: 10.1002/ cncr.27373.

2. Schrey D, Carcel­ler Lechón F, Malietzis G, et al. Multimodal ther­apy in children and adolescents with newly dia­gnosed atypical teratoid rhabdoid tumor: individual pooled data analysis and review of the literature. J Neurooncol 2016;126(1):81– 90. doi: 10.1007/ s11060-015-1904-0.

3. Slavc I, Chocholous M, Leiss U, et al. Atypical teratoid rhabdoid tumor: improved long-term survival with an intensive multimodal ther­apy and delayed radiother­apy. The Medical University of Vien­na Experience 1992– 2012. Cancer Med 2014;3(1):91– 100. doi: 10.1002/ cam4.161.

4. DiPatri AJ, Sredni ST, Grahovac G, et al. Atypical teratoid rhabdoid tumors of the posterior fos­sa in children. Childs Nerv Syst 2015;31(10):1717– 28. doi: 10.1007/ s00381-015-2844-x.

5. Ostrom QT, Chen Y, M de Blank P, et al. The de-scriptive epidemiology of atypical teratoid/ rhabdoid tumors in the United States, 2001-2010. Neuro Oncol 2014;16(10):1392– 9. doi: 10.1093/ neuonc/ nou090.

6. Lafay-Cousin L, Hawkins C, Car­ret AS, et al. Central nervous system atypical teratoid rhabdoid tumours: the Canadian Paediatric Brain Tumour Consortium experience. Eur J Cancer 2012;48(3):353– 9. doi: 10.1016/ j.ejca.2011.09.005.

7. Dufour C, Beaugrand A, Le Deley MC, et al. Clinicopathologic prognostic factors in childhood atypical teratoid and rhabdoid tumor of the central nervous system: a multicenter study. Cancer 2012;118(15):3812– 21. doi: 10.1002/ cncr.26684.

8. Chi SN, Zim­merman MA, Yao X, et al. Intensive multimodality treatment for children with newly dia­gnos­-ed CNS atypical teratoid rhabdoid tumor. J Clin Oncol 2009;27(3):385– 9. doi: 10.1200/ JCO.2008.18.7724.

9. von Hoff K, Hinkes B, Dan­nenman­n-Stern E, et al. Frequency, risk-factors and survival of children with atyp­ical teratoid rhabdoid tumors (AT/ RT) of the CNS dia­g­­-nosed between 1988 and 2004, and registered to the German HIT database. Pediatr Blood Cancer 2011 Dec 1;57(6):978– 85. doi: 10.1002/ pbc.23236.

10. Pai Panandiker AS, Merchant TE, Beltran C, et al. Sequenc­­ing of local ther­apy af­fects the pattern of treatment failure and survival in children with atypical teratoid rhabdoid tumors of the central nervous system. Int J Radiat Oncol Biol Phys 2012;82(5):1756– 63. doi: 10.1016/ j.ijrobp.2011.02.059.

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