Sexual dysfunction in women with multiple sclerosis
Authors:
K. Novotná 1,2; L. Friedová 1; J. Motýl 1; D. Horáková 1; E. Kubala Havrdová 1; M. Andělová 1
Authors place of work:
Neurologická klinika a Centrum klinických neurověd, 1. LF UK a VFN v Praze
1; Klinika rehabilitačního lékařství 1. LF UK a VFN v Praze
2
Published in the journal:
Cesk Slov Neurol N 2025; 88(6): 373-376
Category:
Původní práce
doi:
https://doi.org/10.48095/cccsnn2025373
Summary
Introduction: Sexual dysfunction (SD) is a common, but often underestimated and inadequately addressed symptom in men and women with MS. The prevalence of SD has not been systematically described in Czech MS patients, and therefore our aim was to map the prevalence of SD in women with MS, including possible associated factors. Methods: The standardized questionnaire Female Sexual Function Index (FSFI) was used to assess SD. The FSFI questionnaire was distributed in a long-term prospective study (monitoring disease course and symptoms) to a total of 251 women with MS (mean age of patients was 43.3 ± 8.9 years; with a mean disease duration of 14.7 ± 6.2 years). Results: The complete questionnaire was completed by 147 women (response rate 58.5%). A total of 48 respondents (32.6%) were identified as having SD. When compared with the rate of neurological disability, a weak to moderate negative correlation was found with the total Expanded Disability Status Scale score (0.481; P = 0.002). Patients with SD were older (P = 0.001), with a longer disease duration (P = 0.012) and higher rates of neurological disability (P = 0.001). Conclusion: Sexual dysfunction in women with MS seems to be mainly associated with sensory dysfunction. It was also more prevalent in older women with longer disease duration. Therefore, it is recommended for the clinical practice to ask specifically about the possible occurrence of SD especially in women with sensory symptoms.
Keywords:
Sexual dysfunction – Multiple sclerosis – prevalence – sexuality – EDSS
Zdroje
1. Demirkiran M, Sarica Y, Uguz S et al. Multiple sclerosis patients with and without sexual dysfunction: are there any differences? Mult Scler 2006; 12 (2): 209–214. doi: 10.1191/135248506ms1253oa.
2. Sevene A, Akrour B, Galimard-Maisonneuve E. A et al. Multiple sclerosis and sexuality: a complex model. Sexologies 2009; 18 (2): 86–90. doi: 10.1016/j.sexol.2009.01.011.
3. Pöttgen J, Rose A, van de Vis W et al. Sexual dysfunctions in MS in relation to neuropsychiatric aspects and its psychological treatment: a scoping review. PLoS One 2018; 13 (2): e0193381. doi: 10.1371/journal.pone.0193381.
4. Lysandropoulos AP, Havrdova E, ParadigMS Group. ‚Hidden‘ factors influencing quality of life in patients with multiple sclerosis. Eur J Neurol 2015; 22 (Suppl 2): 28–33. doi: 10.1111/ene.12801.
5. Zámečník L, Dvořáček J. Ženská sexuální dysfunkce. Urol praxi 2004; 2 : 64–66.
6. Cordeau D, Courtois F. Sexual disorders in women with MS: assessment and management. Ann Phys Rehabil Med 2014; 57 (5): 337–347. doi: 10.1016/j.rehab.2014.05.008.
7. Bronner G, Elran E, Golomb J et al. Female sexuality in multiple sclerosis: the multidimensional nature of the problem and the intervention. Acta Neurol Scand 2010; 121 (5): 289–301. doi: 10.1111/j.1600-0404.2009.01314.x.
8. Foley FW, Zemon V, Campagnolo D et al. The multiple sclerosis intimacy and sexuality questionnaire – re-validation and development of a 15-item version with a large US sample. Mult Scler 2013; 19 (9): 1197–1203. doi: 10.1177/1352458512471876.
9. Rosen R, Brown C, Heiman J et al. The female sexual function index (FSFI): a multidimensional self-report instrument for the assessment of female sexual function. J Sex Marital Ther 2000; 26 (2): 191–208. doi: 10.1080/009262300278597.
10. Heřmánková B, Šmucrová H, Mikulášová M et al. Validation of Czech versions of questionnaires assessing female sexual function and pelvic floor function. Čes Revmatol 2021; 1 : 30–40.
11. Stephenson KR, Toorabally N, Lyons L et al. Further validation of the female sexual function index: specificity and associations with clinical interview data. J Sex Marital Ther 2016; 42 (5): 448–461. doi: 10.1080/0092623X.2015.1061078.
12. Wiegel M, Meston C, Rosen R. The female sexual function index (FSFI): cross-validation and development of clinical cutoff scores. J Sex Marital Ther 2005; 31 (1): 1–20. doi: 10.1080/00926230590475206.
13. Kaufman M, Moyer D, Norton J. The significant change for the timed 25-foot walk in the multiple sclerosis functional composite. Mult Scler 2000; 6 (4): 286–290. doi: 10.1177/135245850000600411.
14. Gijbels D, Dalgas U, Romberg A et al. Which walking capacity tests to use in multiple sclerosis? a multicentre study providing the basis for a core set. Mult Scler 2012; 18 (3): 364–371. doi: 10.1177/13524585114 20598.
15. Azimi A, Hanaei S, Sahraian MA et al. Age at menarche and risk of multiple sclerosis (MS): a systematic review and meta-analysis. BMC Neurology 2019; 19 (1): 286. doi: 10.1186/s12883-019-1473-5.
16. Bartnik P, Wielgoś A, Kacperczyk J et al. Sexual dysfunction in female patients with relapsing-remitting multiple sclerosis. Brain Behav 2017; 7 (6): e00699. doi: 10.1002/brb3.699.
17. Konstantidinis C, Tzitzika M, Bantis A et al. Female sexual dysfunction among Greek women with multiple sclerosis: correlations with organic and psychological factors. Sex Med 2019; 7 (1): 19–25. doi: 10.1016/j.esxm.2018.11.003.
18. Mohammadi K, Rahnama P, Mohseni SM et al. Determinants of sexual dysfunction in women with multiple sclerosis. BMC Neurol 2013; 13 : 83. doi: 10.1186/1471-2377-13-83.
19. Hulter BM. Lundberg PO. Sexual function in women with advanced multiple sclerosis. J Neurol Psychiatry 1995; 59 (1): 83–86. doi: 10.1136/jnnp.59.1.83.
20. Lundberg P. Sexual problems in multiple sclerosis. In: Kesselring J. (ed.). Multiple sclerosis: recovery of function and neurorehabilitation. Cambridge: Cambridge University Press 2010.
21. Zivadinov R, Zorzon M, Bosco A et al. Sexual dysfunction in multiple sclerosis: II. Correlation analysis. Mult Scler 1999; 5 (6): 428–431. doi: 10.1191/135245899678846465.
22. Young CA, Tennant A, TONiC Study Group. Sexual functioning in multiple sclerosis: relationships with depression, fatigue and physical function. Mult Scler 2017; 23 (9): 1268–1275. doi: 10.1177/1352458516675749.
23. Foley FF, LaRocca NG, Sanders AS et al. Rehabilitation of intimacy and sexual dysfunction in couples with multiple sclerosis. Mult Scler 2001; 7 : 417–421.
24. Kovari MM, Stovicek J, Novak J et al. Anorectal dysfunction in multiple sclerosis patients: a pilot study on the effect of an individualized rehabilitation approach. NeuroRehabilitation 2022; 50 (1): 89–99. doi: 10.3233/NRE-210226.
25. Šrotová I, Benetinová V, Hladíková M et al. Aspekty ovlivňující kvalitu života u pacientů s roztroušenou sklerózou. Cesk Slov Neurol N 2025; 88 (4): 243–248. doi: 10.48095/cccsnn2025243.
Štítky
Dětská neurologie Neurochirurgie NeurologieČlánek vyšel v časopise
Česká a slovenská neurologie a neurochirurgie
2025 Číslo 6
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