Sclerosis Multiplex and Comorbidity with Another Autoimmune Disease

Authors: J. Szilasiová 1;  I. Lazúrová 2
Authors‘ workplace: Neurologická klinika LF UPJŠ a FN L. Pasteura Košice 1;  I. Interná klinika LF UPJŠ a FN L. Pasteura Košice 2
Published in: Cesk Slov Neurol N 2009; 72/105(1): 51-56
Category: Short Communication


The objective of the study was to assess concomitant incidence of multiple sclerosis (MS) with additional autoimmune diseases in our set of patients and to analyse, in more detail, the impact of such comorbidities on the course of the disease. Patient group and Methods: 256 patients with clinically definitive multiple sclerosis according to McDonald’s criteria. The patients were classified into two groups. Group 1: MS with an additional autoimmune disease. Group 2: SM without an additional autoimmune disease. Results: The average EDSS (Expanded Disability Status Scale) score in the patient set was 3.4 ± 1.4. 23 (8.9%) patients had a concomitant autoimmune disease, the incidence rate being as follows: autoimmune thyroid disease (AIT) – 16; celiac disease – 2, type I diabetes mellitus – 1, rheumatoid arthritis – 1, ulcerous colitis – 1, psoriasis vulgaris – 1, ankylosing spondylitis – 1, and autoimmune hemolytic anaemia – 1. Conclusion: The highest incidence of MS was in patients with concomitant autoimmune thyroid disease. The presence of an additional autoimmune disease did not have a major impact on the degree of functional impairment of patients as compared with the group of patients without any comorbidity. In all cases, autoimmune disease preceded the occurrence of multiple sclerosis.

Key words:
sclerosis multiplex – comorbidity – autoimmune diseases


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