Differential Diagnosis of Neuroacanthocytosis

Authors: J. Klempíř 1;  D. Mikulenková 2;  M. Písačka 2;  O. Klempířová 1
Authors‘ workplace: Neurologická klinika 1. LF UK a VFN, Praha 1;  Ústav klinické a experimentální hematologie 1. LF UK a ÚHKT Praha 2
Published in: Cesk Slov Neurol N 2009; 72/105(1): 24-29
Category: Review Article


Acanthocytes are atypical erythrocytes with sharp membrane protrusions. The range of di­seases classified as neuroacanthocytosis (NA) includes a variety of disorders characterised by the occurrence of acanthocytes together with neurological symptoms. The detection of acanthocytes is, however, not specific and may not necessarily be a symptom of NA. The text describes both the most frequent and rare forms of NA, their etiology, and clinical and laboratory picture. The authors propose their own differential diagnostic approach based on the incidence of atrophy of the caput nuclei caudati which can make diagnosis faster and cheaper.

Key words:
acanthocytes – blood smear – neuroacanthocytosis – chorea – atrophy of caput nuclei caudati – choreoacanthocytosis – McLeod’s syndrome – abetalipoproteinemia


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