The Use of the BOLD Effect when Examining Cerebrovascular Reserve Capacity


Authors: A. Zolal 1;  M. Sameš 1;  P. Vachata 1;  R. Bartoš 1;  M. Nováková 2;  R. Kopáček 3;  M. Derner 2
Authors‘ workplace: Krajská zdravotní, a. s., Masarykova nemocnice v Ústí nad Labem, o. z. Neurochirurgická klinika UJEP 1;  Krajská zdravotní, a. s., Masarykova nemocnice v Ústí nad Labem, o. z. Radiodiagnostické oddělení 2;  Krajská zdravotní, a. s., Masarykova nemocnice v Ústí nad Labem, o. z. Oddělení nukleární medicíny 3
Published in: Cesk Slov Neurol N 2009; 72/105(5): 476-480
Category: Short Communication

Overview

Aim:
To describe the method of cerebrovascular reserve capacity (CVRC) examinati on with the use of a BOLD (blo od oxygenati on level dependent) effect and to present the comparison of the obtained results with the results of SPECT as a standard method.

Pati ents and methods:

This paper describes a gro up of seven pati ents with unilateral internal carotid occlusi on, who underwent CVRC examinati on with BOLD MRI and 99mTc- HMPAO SPECT. The obtained data were preprocessed and two regi ons of interest (ROI) were defined in the perfusi on territory of the middle cerebral artery and in the watershed supraventricular white matter. The results of both examinati ons were a utomatically extracted using these two ROIs, allowing statistical comparison.

Results:
In this gro up of pati ents, a statistically significant (p < 0.01) Pe arson correlati on coeffici ent of 0.716 was fo und for the whole gro up of ROIs (2 ROIs per pati ent). The images resulting from both examinati ons also demonstrate go od correlati on between the two methods, even on visu al inspecti on.

Conclusi on:
The results of CVRC examinati on using BOLD effect correlate well with the results of SPECT. The work confirms the experi ence described in the small number of available internati onal publicati ons, more over, it provides the re ader with a descripti on of a simple, clinically well fe asible methodology of this relatively new CVRC examinati on method.


Sources

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Labels
Paediatric neurology Neurosurgery Neurology
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