Diffusion Tensor Imaging – Current Possibilities of Brain White Matter Magnetic Resonance Imaging

Authors: M. Keřkovský 1;  A. Šprláková-Puková 1;  T. Kašpárek 2;  P. Fadrus 3;  M. Mechl 1;  V. Válek 1
Authors‘ workplace: LF MU a FN Brno Radiologická klinika 1;  LF MU a FN Brno Psychiatrická klinika 2;  LF MU a FN Brno Neurochirurgická klinika 3
Published in: Cesk Slov Neurol N 2010; 73/106(2): 136-142
Category: Review Article


Diffusion tensor imaging (DTI) is a relatively new magnetic resonance imaging technique that is capable of unique depiction of the structural detail in brain white matter. Its sophisticated software algorithms provide either three-dimensional reconstructions and visualizations of the particular tracts of the white matter or quantifications of various DTI parameters that appear, according to certain studies, to be highly sensitive to structural abnormalities in white matter. The aim of the present paper is to review the current applications of DTI for the depiction of brain white matter. Some basic technical remarks are made and clinical aspects are discussed, as well as purely research applications aimed at the detection and quantification of the subtle ultra‑structural pathology of brain white matter.

Key words:
magnetic resonance imaging – diffusion tensor imaging – tractography


1. Basser PJ, Mattiello J, LeBihan D. MR diffusion tensor spectroscopy and imaging. Biophys J 1994; 66(1): 259–267.

2. Assaf Y, Pasternak O. Diffusion tensor imaging (DTI)‑based white matter mapping in brain research: a review. J Mol Neurosci 2008; 34(1): 51–61.

3. Le Bihan D. Molecular diffusion, tissue microdynamics and microstructure. NMR Biomed 1995; 8(7–8): 375–386.

4. Pierpaoli C, Basser PJ. Toward a quantitative assessment of diffusion anisotropy. Magn Reson Med 1996; 36(6): 893–906.

5. Basser PJ. Inferring microstructural features and the physiological state of tissues from diffusion‑weighted images. NMR Biomed 1995; 8(7–8): 333–344.

6. Basser PJ, Pajevic S, Pierpaoli C, Duda J, Aldroubi A. In vivo fiber tractography using DT‑MRI data. Magn Reson Med 2000; 44(4): 625–632.

7. Pajevic S, Pierpaoli C. Color schemes to represent the orientation of anisotropic tissues from diffusion tensor data: application to white matter fiber tract mapping in the human brain. Magn Reson Med 1999; 42(3): 526–540.

8. Conturo TE, Lori NF, Cull TS, Akbudak E, Snyder AZ, Shimony JS et al. Tracking neuronal fiber pathways in the living human brain. Proc Natl Acad Sci U S A 1999; 96(18): 10422–10427.

9. Mori S, Crain BJ, Chacko VP, van Zijl PC. Three‑dimensional tracking of axonal projections in the brain by magnetic resonance imaging. Ann Neurol 1999; 45(2): 265–269.

10. Mukherjee P, Chung SW, Berman JI, Hess CP, Henry RG. Diffusion tensor MR imaging and fiber tractography: technical considerations. AJNR Am J Neuroradiol 2008; 29(5): 843–852.

11. Tournier JD, Yeh CH, Calamante F, Cho KH, Connelly A, Lin CP. Resolving crossing fibres using constrained spherical deconvolution: validation using diffusion‑weighted imaging phantom data. Neuroimage 2008; 42(2): 617–625.

12. Berman JI. Diffusion MR tractography as a tool for surgical planning. Magn Reson Imaging Clin N Am 2009; 17(2): 205–214.

13. Bello L, Gambini A, Castellano A, Carrabba G, Acerbi F, Fava E et al. Motor and language DTI Fiber Tracking combined with intraoperative subcortical mapping for surgical removal of gliomas. Neuroimage 2008; 39(1): 369–382.

14. Berman JI, Berger MS, Chung SW, Nagarajan SS, Henry RG. Accuracy of diffusion tensor magnetic resonance imaging tractography assessed using intraoperative subcortical stimulation mapping and magnetic source imaging. J Neurosurg 2007; 107(3): 488–494.

15. Wei CW, Guo G, Mikulis DJ. Tumor effects on cerebral white matter as characterized by diffusion tensor tractography. Can J Neurol Sci 2007; 34(1): 62–68.

16. Zolal A, Sameš M, Vachata P, Bartoš R, Nováková M, Derner M. Použití DTI traktografie v neuronavigaci při operacích mozkových nádorů: kazuistiky. Cesk Slov Neurol N 2008; 71/104(3): 352–357.

17. Smits M, Vernooij MW, Wielopolski PA, Vincent AJ, Houston GC, van der Lugt A. Incorporating functional MR imaging into diffusion tensor tractography in the preoperative assessment of the corticospinal tract in patients with brain tumors. AJNR Am J Neuroradiol 2007; 28(7): 1354–1361.

18. Sherbondy AJ, Dougherty RF, Napel S, Wandell BA. Identifying the human optic radiation using diffusion imaging and fiber tractography. J Vis 2008; 8(10): 1–11.

19. Nilsson D, Starck G, Ljungberg M, Ribbelin S, Jönsson L, Malmgren K et al. Intersubject variability in the anterior extent of the optic radiation assessed by tractography. Epilepsy Res 2007; 77(1): 11–16.

20. Yogarajah M, Focke NK, Bonelli S, Cercignani M, Acheson J, Parker GJ et el. Defining Meyer‘s loop‑temporal lobe resections, visual field deficits and diffusion tensor tractography. Brain 2009; 132(6): 1656–1668.

21. Harsan LA, Poulet P, Guignard B, Steibel J, Parizel N, de Sousa PL et al. Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging. J Neurosci Res 2006; 83(3): 392–402.

22. Mukherjee P, Miller JH, Shimony JS, Conturo TE, Lee BC, Almli CR et al. Normal brain maturation during childhood: developmental trends characterized with diffusion‑tensor MR imaging. Radiology 2001; 221(2): 349–358.

23. Mukherjee P, Miller JH, Shimony JS, Philip JV, Nehra D, Snyder AZ et al. Diffusion‑tensor MR imaging of gray and white matter development during normal human brain maturation. AJNR Am J Neuroradiol 2002; 23(9): 1445–1456.

24. Guo AC, MacFall JR, Provenzale JM. Multiple sclerosis: diffusion tensor MR imaging for evaluation of normal‑appearing white matter. Radiology 2002; 222(3): 729–736.

25. Andrade RE, Gasparetto EL, Cruz LC jr, Ferreira FB, Domingues RC, Marchiori E et al. Evaluation of white matter in patients with multiple sclerosis through diffusion tensor magnetic resonance imaging. Arq Neuropsiquiatr 2007; 65(3A): 561–564.

26. Bester M, Heesen C, Schippling S, Martin R, Ding XQ, Holst B et al. Early anisotropy changes in the corpus callosum of patients with optic neuritis. Neuroradiology 2008; 50(7): 549–557.

27. Hong YH, Sung JJ, Kim SM, Park KS, Lee KW, Chang KH et al. Diffusion tensor tractography‑based analysis of the pyramidal tract in patients with amyotrophic lateral sclerosis. J Neuroimaging 2008; 18(3): 282–287.

28. Shiga K, Yamada K, Yoshikawa K, Mizuno T, Nishimura T, Nakagawa M. Local tissue anisotropy decreases in cerebellopetal fibers and pyramidal tract in multiple system atrophy. J Neurol 2005; 252(5): 589–596.

29. Prakash N, Hageman N, Hua X, Toga AW, Perlman SL, Salamon N. Patterns of fractional anisotropy changes in white matter of cerebellar peduncles distinguish spinocerebellar ataxia‑1 from multiple system atrophy and other ataxia syndromes. Neuroimage 2009; 47 (Suppl 2): T72–T81.

30. Falkai P, Honer WG, Kamer T, Dustert S, Vogeley K, Schneider‑Axmann T et al. Disturbed frontal gyrification within families affected with schizophrenia. J Psychiatr Res 2007; 41(10): 805–813.

31. Harris JM, Yates S, Miller P, Best JJ, Johnstone EC, Lawrie SM. Gyrification in first‑episode schizophrenia: a morphometric study. Biol Psychiatry 2004; 55(2): 141–147.

32. Honea R, Crow TJ, Passingham D, Mackay CE. Regional deficits in brain volume in schizophrenia: a meta‑analysis of voxel‑based morphometry studies . Am J Psychiatry 2005; 162(12): 2233–2245

33. Van Essen DC. A tension‑based theory of morphogenesis and compact wiring in the central nervous system. Nature 1997; 385(6614): 313–318.

34. Stephan KE, Baldeweg T, Friston KJ. Synaptic plasticity and dysconnection in schizophrenia. Biol Psychiatry 2006; 59(10): 929–939.

35. Kubicki, M, McCarley R, Westin CF, Park HJ, Maier S,Kikinis R et al. A review of diffusion tensor imaging studies in schizophrenia. J Psychiatr Res 2007; 41(1–2): 15–30.

36. Kyriakopoulos M, Bargiotas T, Barker GJ, Frangou S.Diffusion tensor imaging in schizophrenia. Eur Psychiatry 2008; 23(4): 255–273.

37. Shin YW, Kwon JS, Ha TH, Park HJ, Kim DJ, Hong SB et al. Increased water diffusivity in the frontal and temporal cortices of schizophrenic patients. Neuroimage 2006; 30(4): 1285–1291.

38. Mukherjee P, Hess CP, Xu D, Han ET, Kelley DA, Vigneron DB. Development and initial evaluation of 7-T q‑ball imaging of the human brain. Magn Reson Imaging 2008; 26(2): 171–180.

39. Hess CP, Mukherjee P, Han ET, Xu D, Vigneron DB. Q‑ball reconstruction of multimodal fiber orientations using the spherical harmonic basis. Magn Reson Med 2006; 56(1): 104–117.

Paediatric neurology Neurosurgery Neurology
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