Progressing Spasticity, Cognitive Deficit and Non-elicitable Cortical Motor Evoked Potentials as Signs of Probable Primary Lateral Sclerosis – a Case Report

Authors: A. Kopal 1;  E. Ehler 1;  I. Rektorová 2,3
Authors‘ workplace: Neurologická klinika, Pardubická krajská nemocnice 1;  Výzkumná skupina Aplikované neurovědy, Středoevropský technologický institut, CEITEC MU, Brno 2;  I. neurologická klinika LF MU a FN u sv. Anny v Brně 3
Published in: Cesk Slov Neurol N 2011; 74/107(5): 579-583
Category: Case Report


Motor neurone diseases comprise a heterogeneous group of disorders that affect the upper motor neurone and/or the lower motor neurone. Both amyotrophic lateral sclerosis and primary lateral sclerosis fall into the category of motor neurone diseases. Amyotrophic lateral sclerosis is usually defined as a fatal neurodegenerative disorder that progressively affects both the upper and lower motor neurone, with mean survival between three and five years, although long-term survival may occur, albeit infrequently. Primary lateral sclerosis is an idiopathic, non-familial neurodegenerative disorder of the upper motor neurone.

Key words:
motor neurone diseases – primary lateral sclerosis – amyotrophic lateral sclerosis – spasticity – motor evoked potentials – cognitive deficit


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