The Prevention of Venous Thrombosis and Pulmonary Embolism in Neurosurgery

Authors: D. Krahulík 1;  V. Krčová 2;  M. Vaverka 1;  L. Hrabálek 1
Authors‘ workplace: FN a LF UP Olomouc Neurochirurgická klinika 1;  FN a LF UP Olomouc Hemato-onkologická klinika 2
Published in: Cesk Slov Neurol N 2011; 74/107(5): 560-563
Category: Short Communication


The authors apply guidelines for the prevention of deep venous thrombosis in neurosurgery. These guidelines are based on the recommendations of section of thrombosis and haemo­stasis, of the Hematology Society and the recommendations of the American and Canadian Society of Haematology.

Key words:
venous thrombosis – pulmonary embolism – prevention – neurosurgery


1. Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR et al. Prevention of venous thromboembolism. Chest 2008; 133 (Suppl 6): 381S–453S.

2. Gumulec J, Penka M, Bezděk R. Prevence žilní trombózy a plicní embolizace v chirurgii, v cévní chirurgii a v urologické chirurgii [online]. Dostupné z URL:

3. Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW et al. Prevention of venous thromboembolism. the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004; 126 (Suppl 3): 338S–400S.

4. Sullivan SD, Kahn SR, Davidson BL, Borris L, Bossuyt P, Raskob G. Measuring the outcomes and pharmacoeconomic consequences of venous thromboembolism prophylaxis in major orthopedic surgery. Pharmaco­economics 2003; 21(7): 477–496.

5. Geerts WH, Heit JA, Clagett GP, Pineo CF, Colwell CW, Anderson FA jr et al. Prevention of venous thromboembolism. Chest 2001; 119 (Suppl 1): 132S–175S.

6. Heit JA. Venous thromboembolism prophylaxis. Hematology 1999; 10: 223–230.

7. Malý J, Widimský J. Prevence plicní embolie a žilní trombózy. In: Widimský J, Malý J et al (eds). Akutní plicní embolie a žilní trombóza. Patogeneze, diagnostika a prevence. 2nd ed. Praha: Triton 2005: 289–302.

8. Mismetti P, Laporte S, Darmon JY, Buchmüller A, Decousus H. Meta-analysis of low molecular weight heparin in the prevention of venous thrombo­embolism in general surgery. Br J Surg 2001; 88(7): 913–930.

9. Ruff RL, Posner JB. Incidence and treatment of peripheral venous thrombosis in patients with glioma. Ann Neurol 1983; 13(3): 334–336.

10. Wen DY, Hall WA. Complications of subcutaneou slow-dose heparin therapy in neurosurgical patients. Surg Neurol 1998; 50(6): 521–525.

11. Goldhaber SZ, Dunn K, Gerhard-Herman M, Park JK, Black PM. Low rate of venous thromboembolism after craniotomy for brain tumor using multimodality prophylaxis. Chest 2002; 122(6): 1933–1937.

12. Iorio A, Agnelli G. Low-molecular-weight and unfractionated heparin for prevention of venous tromboembolism in neurosurgery: a meta-analysis. Arch Intern Med 2000; 160(15): 2327–2332.

13. Simanek R, Vormittag R, Hassler M, Roessler K, Schwarz M, Zielinski C, Pabinger I et al. Venous thromboembolism and survival in patients with high-grade glioma. Neuro Oncol 2007; 9(2): 89–95.

14. Clagett GP, Reisch JS. Prevention of venous thromboembolism in general surgical patients: results of meta-analysis. Ann Surg 1988; 208(2): 227–240.

15. Nicolaides A, Irving D, Pretzell M, Dupont P, Lewis J, Denai S et al. The risk of deep-vein thrombosis in surgical patients. Br J Surg 1973; 60(4): 312.

16. Kakkar VV. Low dose heparin in the prevention of venous thromboembolism. Thromb Diath Haemorrh 1974; 33(1): 87–96.

17. Agnelli G, Bergqvist D, Cohen AT. Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venoust hromboembolism in high-risk abdominal surgery. Br J Surg 2005; 92(10): 1212–1220.

Paediatric neurology Neurosurgery Neurology

Article was published in

Czech and Slovak Neurology and Neurosurgery

Issue 5

2011 Issue 5

Most read in this issue
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.


Don‘t have an account?  Create new account