Homocysteine and Multiple Sclerosis

Authors: M. Cingelová;  L. Procházková;  J. Martinková;  P. Kukumberg
Authors‘ workplace: II. Neurologická klinika LF UK a UN Bratislava
Published in: Cesk Slov Neurol N 2013; 76/109(5): 565-569
Category: Review Article


Multiple sclerosis (MS) is a chronic inflammatory autoimunne disorder that affects central nervous system. The etiology of MS remains unknown. Genetic predisposition combined with environmental factors seem to be involved. Recently, homocysteine has been proposed as a potentially important player in MS pathogenesis, not only during disease development but during disease progression as well. Among the MS-linked psychiatric problems, the association between hyperhomocysteinemia (hyperHCy) and depression and cognitive dysfunction is the most researched. HyperHCy might be inherited or acquired. The most common cause of acquired HCy includes vitamin B12 and folate deficiency, chronic renal failure, hypothyreoidism and chronic drug exposure. Therefore, it is important to identify these comorbidities or risk factors early, as they may impact on the pathogenesis and course of MS.

Key words:
multiple sclerosis – homocysteine – depression – cognitive impairment

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.


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