MicroRNAs in Cerebrovascular Diseases –  from Pathophysiology to Potential Biomarkers


Authors: O. Volný 1,2;  L. Kašičková 3;  D. Coufalová 2,3;  P. Cimflová 2,4;  J. Novák 5,6
Authors‘ workplace: I. neurologická klinika LF MU a FN u sv. Anny v Brně 1;  ICRC – Mezinárodní centrum klinického výzkumu, FN u sv. Anny v Brně 2;  Lékařská fakulta MU, Brno 3;  Klinika zobrazovacích metod LF MU a FN u sv. Anny v Brně 4;  II. interní klinika LF MU a FN U sv. Anny v Brně 5;  Fyziologický ústav, LF MU, Brno 6
Published in: Cesk Slov Neurol N 2016; 79/112(3): 287-293
Category: Review Article

Overview

Small non-coding molecules of ribonucleic acid are important regulators of gene expression and translation. One group of non-coding RNAs is represented by microRNA – 22-24 nucleotides long RNA molecules with effects on regulation of proteins synthesis. Many of them are tissue or organ specific (e. g. miR-206 in striated muscles or miR-122 in hepatocytes). These molecules are enzyme-resistant and detectable in both intracellular and extracellular space. Currently, these molecules are intensively studied as potential markers in many diseases including cerebrovascular diseases. In this review we provide insight into the recent knowledge from animal to human studies concerning miRNAs, with the special emphasis put on diagnostic, therapeutic and prognostic potentials in ischemic stroke (let-7, miR-7, miR-21, miR-29, miR-124, miR-181, miR-210, miR-223), intracranial aneurysms (miR-21, miR-26, miR-29, miR-143/145), and brain arterio-venous malformations (miR-18a).

Key words:
microRNA – ischemic stroke – intracranial aneurysma – cerebral arterio-venous malformations

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.


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