Laboratory ef­ficacy test­­ing of acetylsalicylic acid treatment in secondary prevention of ischemic stroke

Authors: T. Adámek 1;  Z. Paluch 2;  L. Sadílková 1;  Š. Alušík 3
Authors‘ workplace: Interní oddělení, Thomayerova nemocnice, Praha 1;  Ústav farmakologie, 2. LF UK, Praha 2;  Katedra vnitřního lékařství, Institut postgraduálního vzdělávání ve zdravotnictví, Praha 3
Published in: Cesk Slov Neurol N 2019; 82(1): 84-90
Category: Original Paper



To as­sess the ef­ficacy of antiplatelet ther­apy with acetylsalicylic acid (ASA) in secondary prevention in a strictly selected group of patients after ischemic stroke.

Patients and methods:

The group included 106 patients with a minimum of factors potential­ly af­fect­­ing the ef­fect of ASA. While compliance was verified by laboratory determination of ASA levels in plasma, presence of previous embolic events was minimized by thorough examination of the heart and carotid arteries. All patients tak­­ing 100 mg of ASA  daily had their serum 11-dehydrotromboxane B2 levels determined.


Even in this strictly selected set of patients, ef­fective thromboxane suppres­sion (95% and higher) was only achieved in 76 patients, with suppres­sion levels of 80– 94.9% determined in 24 patients, and lower in another six patients. Patients with inadequate thromboxane suppres­sion had statistical­ly higher body mass index, cholesterol and LDL cholesterol, and uric acid levels.


While ASA use led to marked thromboxane suppres­sion in all patients, the required level of suppres­sion was not achieved in over a fourth of our patients. Consistent with latest reports, it is likely that the seemingly inadequate suppres­sion of thromboxane is due to its production from sources other than platelets.

Key words:

acetylsalicylic acid – ischemic stroke – 11-dehydrothromboxane

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.







即使在这组严格选择的患者中,有效的血栓素抑制(95%及以上)仅在76例患者中实现,其中24例患者的抑制水平为80 - 94.9%,另外6例患者的抑制水平较低。血栓素抑制不足的患者,其体重指数、胆固醇和低密度脂蛋白胆固醇以及尿酸水平均有统计学意义上的升高。




乙酰水杨酸-缺血性脑卒中- 11-脱氢血栓素



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