Comorbidities of Alzheimer‘s disease – results of a multicentric observational COSMOS study in the Slovak Republic

Authors: M. Minár 1;  J. Dragašek 2;  I. Mátéffy 3;  P. Valkovič 1,4
Authors‘ workplace: II. neurologická klinika LF UK a UN Bratislava, Slovensko 1;  I. psychiatrická klinika LF UPJŠ Košice, Slovensko 2;  Psychiatrická klinika SZU UN Bratislava, Slovensko 3;  Ústav normálnej a patologickej fyziológie, Slovenská akadémia vied, Bratislava, Slovensko 4
Published in: Cesk Slov Neurol N 2020; 83(1): 95-99
Category: Original Paper
doi: 10.14735/amcsnn202095


Aim: Alzheimer‘s disease (AD) is one of the most disabling conditions predominantly affecting an elderly population. Data suggest that comorbidities complicate both dia­gnosis and treatment and accelerate AD progression. Epidemiological data from the Central Europe are missing, therefore, the aim of the COSMOS project was to reveal the prevalence of psychiatric and somatic comorbidities among AD patients in the Slovak population.

Methods: In this multicenter, cross--sectional, observational study, data of AD patients from all Slovak regions (89 sites) were obtained using an online questionnaire. It contained demographic and clinical data, information about all comorbidities, and their impact on adherence and tratment efficacy.

Results: Out of all 494 patients, 94.53% had at least one somatic comorbidity, 80.16% had at least one psychiatric comorbidity. The number of both somatic (rs = 0.120; P = 0.008) and psychiatric (rs = 0.267; P < 0.001) comorbidities correlated with the severity of AD. The number of psychiatric comorbidities (b = –0.021; P = 0.025) and the severity of AD (b = –0.071; P < 0.001) predicted a worse therapy effect. Adherent patients were more likely to have effective therapy of dementia (OR 5.270; 95% CI 3.061–9.073; P < 0.001).

Conclusion: Comorbidities in AD have been shown to accelerate progression of underlying disease and complicate dia­gnosis and therapy. However, they represent the most modifiable factors of cognitive deterioration. Their active screening, early dia­gnosis and adequate therapy can improve patient’s adherence and, thus, make AD management more effective.


Alzheimer‘s disease – comorbidities – psychiatric – somatic – therapy – adherence


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