Neuropsychiatric symp­toms as early manifestation of Alzheimer’s dis­ease


Authors: V. Matušková;  T. Nikolai;  H. Marková;  K. Čechová;  J. Laczó;  J. Hort;  M. Vyhnálek
Authors‘ workplace: Neurologická klinika 2. LF UK a FN Motol, Praha ;  Mezinárodní centrum klinického výzkumu, FN u sv. Anny v Brně
Published in: Cesk Slov Neurol N 2020; 83(1): 64-72
Category: Original Paper
doi: 10.14735/amcsnn202064

Overview

Aim: Neuropsychiatric symp­toms (NPS) are a heterogeneous group of changes in personality and behavior that can be observed already in early stages of Alzheimer’s dis­ease (AD). Mild behavioral impairment (MBI) is a newly developed dia­gnostic category describ­­ing persistent changes in personality and behavior start­­ing later in life. Based on these criteria, a new measure, the Mild Behavioral Impairment Checklist (MBI-C) has been developed, aimed at detect­­ing NPS in early stages of AD. The aim of this study is to present the newly adapted Czech version of the MBI-C and to explore the presence of NPS in a pilot group of patients.

Patients and methods: The original MBI-C has been adapted to Czech and administered to close informants of 188 patients. The patients were divided accord­­ing to the results of a complex neuropsychological, neurological examination and brain imag­­ing into 3 groups: cognitively normal (N = 69), amnestic mild cognitive impairment (aMCI; N = 87) and dementia due to AD (N = 32).

Results: Patients with aMCI expres­sed in the MBI-C significantly more severe score compared to cognitively normal subjects and less severe compared to dementia patients. The dif­ferences were observed mainly in af­fective, motivation and impulse control domains.

Conclusion: The Czech version of the MBI-C detects the presence of NPS even before the onset of dementia syndrome and is useful in clinical practice.

Keywords:

neuropsychiatric symptoms – Alzheimer´s disease – mild behavioral impairment – mild cognitive impairment


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