Pharmacological Neuroprotection in Acute Ischemic Stroke


Authors: MUDr. Jan Mraček
Authors‘ workplace: Neurochirurgické oddělení LF UK a FN Plzeň
Published in: Cesk Slov Neurol N 2011; 74/107(1): 22-28
Category: Review Article

Overview

Neuroprotection is a strategy that works against the biochemical and molecular manifestations that lead to ischemic brain injury. The aim of neuroprotection is to protect the hypoperfused region of the brain through influencing the ischemic cascade and by reducing the progress of injurious reperfusion. The development of neuroprotection has proceeded in tandem with a growing understanding of the pathophysiology of brain ischemia. In spite of the demonstrable effects of many agents in animal models, to date none of the neuroprotective agents tested has been shown to improve the outcome in a phase III clinical trial. This review presents the drugs most extensively evaluated in preclinical and clinical trials.

Key words:
neuroprotection – stroke – ischemia – therapeutic window – clinical trial


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