Neurological Complications Associated with Assisted Reproductive Technology – a Case Report

Authors: I. Okáčová 1;  Y. Benešová 1;  P. Štouračihash2 1,2 1,2
Authors‘ workplace: Neurologická klinika LF MU a FN Brno 1;  CEITEC – Středoevropský techno­logický institut MU, Brno 2;  Radiologická klinika LF MU a FN Brno 3
Published in: Cesk Slov Neurol N 2012; 75/108(5): 637-640
Category: Case Report


Assisted reproductive techniques using hormonal ovarian hyperstimulation and intended induction of ovulation are the most important scientific and therapeutic discoveries in the treatment of sterility made over the last decades. This treatment is associated with a risk of a varied degree ovarian hyperstimulation syndrome. The aim of this review is to emphasize some neurological complications possibly resulting from ovarian stimulation. Cerebral strokes are the most important complications of ovarian stimulation. We present a case of ischemic stroke after a controlled ovarian hyperstimulation regimen in a previously healthy 27-year-old woman. An increased rate and intensity of headaches, mostly in patients with chronic migraine, is another neurological complication. In the second case report, we present a 35-year-old woman suffering from complicated migraine developed after ovarian stimulation. Treatment-induced hormonal fluctuation may have negative effect on the activity and susceptibility to autoimmune diseases, such as multiple sclerosis. In the third case report, we present a 37-year-old patient with the first attack of multiple sclerosis after ovarian stimulation.

Key words:
assisted reproductive technology – ovarian hyperstimulation syndrome – neurological complications


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Paediatric neurology Neurosurgery Neurology

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