Thalamic Germinoma in a Child with Symptoms of Precocious Pseudopuberty – a Case Report

Czech version

Authors: Z. Pavelka ¹; O. Magnová ²; L. Křen ³; T. Svoboda ⁴; E. Brichtová ⁵; J. Štěrba ¹
Authors‘ workplace: LF MU Brno a FN Brno Klinika dětské onkologie ¹; LF MU Brno a FN Brno Pediatrická klinika ²; LF MU Brno a FN Brno Ústav patologie ³; LF MU Brno a FN Brno Neurochirurgická klinika ⁴; LF MU Brno a FN Brno Neurochirurgické oddělení Kliniky dětské chirurgie, ortopedie a traumatologie ⁵
Published in: Cesk Slov Neurol N 2013; 76/109(4): 497-500
Category: Case Report

Overview

We describe a case of a 6 years old boy with germinoma of an unusual thalamic localization that presented with precocious pseudopuberty based on ectopic human chorionic gonadotropin (hCG) secretion. The tumour was confirmed with stereotactic biopsy; subsequent chemotherapy and radiotherapy led to complete remission. The mechanism of precocious pseudopuberty and clinical and treatment aspects of brain germinomas in children arediscussed.

Key words:
germinoma – central nervous system – human chorionic gonadotropin – pseudopuberty – chemotherapy – radiotherapy

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