Thalamic Germinoma in a Child with Symptoms of Precocious Pseudopuberty –  a Case Report

Authors: Z. Pavelka 1;  O. Magnová 2;  L. Křen 3;  T. Svoboda 4;  E. Brichtová 5;  J. Štěrba 1
Authors‘ workplace: LF MU Brno a FN Brno Klinika dětské onkologie 1;  LF MU Brno a FN Brno Pediatrická klinika 2;  LF MU Brno a FN Brno Ústav patologie 3;  LF MU Brno a FN Brno Neurochirurgická klinika 4;  LF MU Brno a FN Brno Neurochirurgické oddělení Kliniky dětské chirurgie, ortopedie a traumatologie 5
Published in: Cesk Slov Neurol N 2013; 76/109(4): 497-500
Category: Case Report


We describe a case of a 6 years old boy with germinoma of an unusual thalamic localization that presented with precocious pseudopuberty based on ectopic human chorionic gonadotropin (hCG) secretion. The tumour was confirmed with stereotactic biopsy; subsequent chemotherapy and radiotherapy led to complete remission. The mechanism of precocious pseudopuberty and clinical and treatment aspects of brain germinomas in children arediscussed.

Key words:
germinoma – central nervous system – human chorionic gonadotropin – pseudopuberty – chemotherapy – radiotherapy


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Paediatric neurology Neurosurgery Neurology

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Czech and Slovak Neurology and Neurosurgery

Issue 4

2013 Issue 4

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