Glioblastoma Multiforme with Simultaneous Leptomeningeal and Intramedulary Metastases – a Case Study


Authors: J. Kasík 1;  L. Loudová 1;  M. Tinková 1;  F. Charvát 2;  P. Hrabal 3
Authors‘ workplace: ÚVN – Vojenská FN Praha Neurologické oddělení 1;  ÚVN – Vojenská FN Praha Radiologické oddělení 2;  ÚVN – Vojenská FN Praha Patologicko-anatomické oddělení 3
Published in: Cesk Slov Neurol N 2014; 77/110(3): 368-372
Category: Case Report

Overview

Glioblastoma multiforme is known for its infiltrative growth into surrounding tissues as well as for dissemination of tumor cells into distant nerve structures via cerebrospinal fluid. Unlike primary brain tumors, clinical presentation of metastasis is sporadic or rare. We present a young man, who developed a clinical manifestation of a rare variant of simultaneous metastasis.

Key words:
glioblastoma multiforme – leptomeningeal metastasis – intramedullary metastasis

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.


Sources

1. Lakomý R, Burkoň P, Burkoňová D, Jančálek R. Nové možnosti léčby glioblastoma multiforme. Klin Onkol 2010; 23 (6): 381– 387.

2. Stark AM, Nabavi A, Mehdorn HM, Blömer U. Glioblastoma multiforme‑ report of 267 cases treated at a single institution. Surg Neurol 2005; 63(2): 162– 169.

3. Didelot A, Taillandier L, Grignon Y, Vespignani H, Beauchesne P. Concomitant bone marrow metastasis of a glioblastoma multiforme revealed at the dia­gnosis. Acta Neurochir (Wien) 2006; 148(9): 997– 1000.

4. Bailey P, Cusching H. Tumor of the glioma group. Philadelphia: JB Lippincott 1926.

5. Caims H, Russell DS (eds). Intracranial and spinal metastases in gliomas of the brain. Brain 1931; 54: 377– 420.

6. Eden KC. Dissemination of a glioma of the spinal cord in the leptomeninges. Brain 1938; 61: 289– 310.

7. Arita N, Taneda M, Hayakawa T. Leptomeningeal dissemination of malignant gliomas. Incidence, dia­gnosis and outcome. Acta Neurochir (Wien) 1994; 126(2– 4): 84– 92.

8. Hübner F, Braun V, Richter HP. Case reports of symp­tomatic metastasis in four pacients with primary intracranial gliomas. Acta Neurochir (Wien) 2001; 143: 25– 29.

9. Karaca M, Andrieu MN, Hicsonmez A, Guney Y, Kurtman C. Cases of glioblastoma multiforme metastasizing to spinal cord. Neurol India 2006; 54(4): 428– 430.

10. Scoccianti S, Detti B, Meattini I, Iannalfi A, Sardaro A, Leonulli BG et al. Symptomatic leptomeningeal and intramedullary metastases from intracranial glioblastoma multiforme: a case report. Tumori 2008; 94(6): 877– 881.

11. Balhuizen JC, Bots GT, Schaberg A, Bosman FT. Value of cerebrospinal fluid cytology for the dia­gnosis of malignancies in the central nervous system. J Neurosurg 1978; 48(5): 747– 753.

12. Giese A, Westphal M. Glioma invasion in the central nervous system. Neurosurg 1996; 39(2): 235– 252.

13. Krisch B, Leonhard H, Okshe A. Compartments and perivascular arrangement of the meninges covering the cerebral cortex of the rat. Cell Tissue Res 1984; 238(3): 459– 474.

14. Kumar R, Jain R, Tandon V. Thalamic glioblastoma with cerebrospinal fluid dissemination in the peritoneal cavity. Pediatr Neurosurg 1999; 31(5): 242– 245.

15. Grabb PA, Albright AL, Pang D. Dissemination of supratentorial malignant gliomas via the cerebrospinal fluid in children. Neurosurg 1992; 30(1): 64 – 71.

16. Fakhrai N, Czech T, Diekmann K, Dörner BF, Birner P, Hainfellner JA et al. Glioblastoma with spinal seeding. Strahlenther Onkol 2004; 180(7): 455– 457.

17. Choi PP, Shapera S. What’s your call? Drop metastases. CMAJ 2006; 175(5): 475– 477.

18. Vertosick FT jr, Selker RG. Brain stem and spinal metastases of supratentorial glioblastoma multiforme: a clinical series. Neurosurgery 1990; 27(4): 516– 521.

Labels
Paediatric neurology Neurosurgery Neurology

Article was published in

Czech and Slovak Neurology and Neurosurgery

Issue 3

2014 Issue 3

Most read in this issue

This topic is also in:


Login
Forgotten password

Don‘t have an account?  Create new account

Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account