Less Common Indications for Deep Brain Stimulation

Authors: J. Chrastina 1,2;  Z. Novák 1,2;  M. Baláž 2,3;  I. Říha 1,2;  D. Hrabovský 1;  M. Brázdil 2,3
Authors‘ workplace: Neurochirurgická klinika LF MU a FN U sv. Anny v Brně 1;  CEITEC – Středoevropský technologický institut MU, Brno 2;  I. neurologická klinika LF MU a FN u sv. Anny v Brně 3
Published in: Cesk Slov Neurol N 2014; 77/110(3): 302-307
Category: Review Article

Podpořeno projektem CEITEC CZ.1.05/ 1.1.00/ 02.0068.


Movement disorders, mainly late motor complications of Parkinson’s disease, dystonia and essential tremor are the most common indications for deep brain stimulation. Literature also provides positive results for deep brain stimulation applied in selected patients with intractable epilepsy and refractory pain. The results of deep brain stimulation in selected patients with certain refractory psychiatric disorders (e.g. treatment resistant depression and obsessive compulsive disorder) are encouraging. Deep brain stimulation was also used in small cohorts of patients with various serious refractory disorders, such as uncontrollable aggression, eating disorders, morbid obesity, vegetative state, Alzheimer disease, and drug and alcohol abuse. The paper aims to present an overview of these less frequent indications of deep brain stimulation, basic data about stimulation target structures, description of the clinical data available so far, practical surgical considerations and a short prospective of further use of deep brain stimulation in patients suffering from the serious functional problems described above.

Key words:
deep brain stimulation – aggression –anorexia nervosa – obesity – vegetative state – Alzheimer disease – drug addiction

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.


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