Genetic Variability in Attention Deficit Hyperactivity Disorder

Authors: H. Kuželová 1,2;  M. Macek Jr 1;  J. Raboch 2;  R. Ptáček 2
Authors‘ workplace: 2. LF UK v Praze, FN v Motole, Praha 1;  Psychiatrická klinika 1. LF UK a VFN v Praze 2
Published in: Cesk Slov Neurol N 2014; 77/110(4): 423-427
Category: Review Article

Tento článek byl podpořen výzkumnými granty IRP 610- 09- 236025- 26, IRP 610- 09-336025- 26, VPK 205003- 1, CZ.2.16/ 3.1.00/ 24022OPPK a IP 6003 FN v Motole č. 00064203.


Attention deficit hyperactivity disorder (ADHD) is a common, probably highly genetically conditioned, neurobiological disorder. Heritability of ADHD symptoms is up to about 75%. However, the mechanism is still not fully understood. Attention is focused mainly on genes of the dopaminergic and serotonergic system as well as many other genes. The paper presents a summary of the most significant genetic associations with ADHD.

Key words:
attention deficit hyperactivity disorder – genetics – gene variant


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