Progressive Dementia with Parkinsonism and Behavioral Changes –  from the First Manifestations to the Neuropathological Confirmation (a Case Study)

Authors: V. Franková 1;  R. Matěj 2,3;  R. Rusina 3,4
Authors‘ workplace: Psychiatrická nemocnice v Dobřanech 1;  Oddělení patologie a molekulární medicíny, Thomayerova nemocnice, Praha 2;  Neurologická klinika a Centrum klinických neurověd 1. LF UK a VFN v Praze 3;  Neurologické oddělení, Thomayerova nemocnice, Praha 4
Published in: Cesk Slov Neurol N 2015; 78/111(2): 209-214
Category: Case Report


We describe a case of a 69-year-old man with an atypical course of dementia with Parkinsonism and progressive severe behavioral abnormalities. Clinical presentation was compatible with dementia with Lewy bodies or frontotemporal dementia with Parkinsonism. The rapid and atypical progression was related to neuropathological findings of two co-morbid neurodegenerative entities. Fully developed dementia with Lewy bodies predominated, while markers of Alzheimer’s disease were also present in the brain tissue. However, their less expressed and more widespread distribution was probably related to the absence of clinical manifestations of progressive amnestic dementia, a typical symptom of Alzheimer’s disease. We retrospectively completed missing data and retraced the clinical course from the first disease manifestations to the definite neuropathological diagnosis.

Key words:
delirium – dementia with Lewy bodies –Alzheimer’s disease – frontotemporal dementia – differential diagnosis – parkinsonism

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.


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