Validation of the Czech Version of the Quantitative Sensory Testing Protocol


Authors: I. Šrotová 1,2;  E. Vlčková 1,2;  J. Straková 1;  S. Kinclová 1,2;  B. Adamová 1,2;  L. Dušek 3;  J. Jarkovský 3 ;  J. Bednařík 1,2
Authors‘ workplace: Neurologická klinika LF MU a FN Brno 1;  CEITEC – Středoevropský technologický institut, MU, Brno 2;  Institut biostatistiky a analýz, LF a PřF MU, Brno 3
Published in: Cesk Slov Neurol N 2015; 78/111(4): 442-452
Category: Original Paper

Overview

Background:
Quantitative sensory testing (QST) following the protocol of the German Research Network on Neuropathic Pain (DFNS) is frequently used for the evaluation of sensory profi les in neuropathic pain patients. It covers a broad spectrum of sensory modalities using both nociceptive and non-nociceptive thermal and mechanical stimuli. The protocol requires the use of standardized instructions and thus necessitates validation of each language version.

Material and methods:
The standardized instructions for DFNS-QST protocol were translated using the forward-backward translation method and validated in a group of patients suffering from neuropathic pain of peripheral (n = 68) or central origin (n = 59) due to painful diabetic polyneuropathy or multiple sclerosis, and in a group of healthy volunteers (n = 75). The testing was repeated four times (with one-month interval between examinations) in 26 individuals to determine test-retest reliability.

Results:
In a group of healthy volunteers, 95% of values across all the parameters were within the physiological range based on published normal data. At least one sensory abnormity was found in 90% of neuropathic pain patients. Cluster analysis identified two distinctive pain profiles, the first mostly consisted of patients with painful diabetic neuropathy and the second of patients with pain in multiple sclerosis. Repeated administration confirmed an acceptable test-retest reliability (Cronbach´s alpha of 0.59–0.93 for the different sensory modalities).

Conclusion:
The Czech version of DFNS-QST protocol instructions displayed a good practical applicability in evaluating sensory abnormities in neuropathic pain patients, acceptable reliability and high internal consistency of the findings. The protocol provides results comparable to the original language version and can be recommended as an easy-to-apply and suitable testing method.

Key words:
neurological examination – sensory threshold – pain threshold – quantitative evaluation - neuropathic pain – diabetic neuropathy – multiple sclerosis

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.


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Paediatric neurology Neurosurgery Neurology

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Czech and Slovak Neurology and Neurosurgery

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