Multiple system atrophy

Authors: J. Klempíř 1,2,3;  T. Bartošová 1,2
Authors‘ workplace: Neurologická klinika a Centrum klinických neurověd, 1. LF UK a VFN v Praze 1;  Anatomický ústav, 1. LF UK v Praze 2;  Evropská referenční síť pro vzácná neurologická onemocnění 3
Published in: Cesk Slov Neurol N 2019; 82(4): 370-380
Category: Review Article
doi: 10.14735/amcsnn2019370


Multiple system atrophy (MSA) is relatively rare neurodegenerative dis­ease with fatal prognosis af­fect­­ing middle-aged and elderly individuals. There is combination of several motor and non-motor symp­toms in MSA. Causal treatment does not exist and symp­tomatic treatment ef­fect is unsatisfactory. The article briefly discus­ses genetics and pathophysiology of MSA with special focus on the clinical picture, practical aspects of dia­gnostics and cur­rent therapeutic options of MSA in the Czech Republic.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.


multiple system atrophy – atypical parkinsonian syndrome – alpha synuclein – REM sleep behavioral disorders – autonomic dysfunction – orthostatic hypotension – inspiratory stridor


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