Lipid Levels in Gli oblastoma Multiforme and the Role of Ki 67 Index in the Determinati on of Proliferati on Activati on


Hladiny lipidů u gli oblastomu a úloha indexu Ki 67 při určování aktivace proliferace

Cíle:
Cílem této studi e bylo hledat so uvislost mezi hladinami lipidů a indexem Ki 67 a hodnoto u indexu Ki 67 při určování proliferační aktivity multiformního gli oblastomu (GBM).

Materi ál a metodika:

Do studi e bylo zařazeno 16 paci entů s GBM, kteří prodělali operativní léčbu. U všech paci entů byla provedena předoperační magnetická rezonance (MR) a MR spektroskopi e. Hladiny lipidů u všech paci entů byly zaznamenány. Při patologickém vyšetření byl vypočítán procentu ální poměr počtu buněk označených jaderným barvením Ki 67 a počtu všech buněk. So uvislost mezi hladinami lipidů a indexem Ki 67 v uvedených případech byla analyzována.

Výsledky:
V uvedených případech neexistoval žádný významný vztah mezi věkem, pohlavím a indexem Ki 67 a hladinami lipidů. Významné bylo dosažení hodnoty 350 jako nejnižší hodnoty lipidů při multiformním gli oblastomu. Neexistoval žádný významný vztah mezi indexem Ki 67 a hladinami lipidů.

Závěry:
Index Ki 67 nemá žádný význam při určování léčebné strategi e u paci entů s di agnostikovaným GBM. Proto se nedomníváme, že by studi e indexu Ki 67 měla být rutinní so učástí laboratorního vyšetření paci entů s GBM.

Klíčová slova:
multiformní gli oblastom –  index Ki 67 –  hladina lipidů –  MR spektroskopi e


Authors: M. Kaplan 1;  E. Gercek 1;  H. I. Secer 2;  A. Ozer 3;  H. Yildirim 4;  N. Akpolat 5;  M. Koparan 1
Authors‘ workplace: Firat University, Department of Ne urosurgery, Elazig, Turkiye, 2Gulhane Military Medical Academy, Department of Ne urosurgery, Ankara, Turkiye, 3Beydagi Hospital, Malatya, Turkiye, 4Firat University Department of Radi ology, Elazig, Turkiye, 5Firat Unive 1
Published in: Cesk Slov Neurol N 2009; 72/105(3): 242-244
Category: Original Paper

Overview

Aims:
The aim of this study was to lo ok for an associ ati on between lipid levels and the Ki 67 index and the value of the Ki 67 index in the determinati on of proliferative activity in gli oblastoma multiforme (GBM).

Materi als and methodology:

Sixteen pati ents with GBM who had undergone surgical tre atment were included in the study. Pre‑operative magnetic resonance (MRI) and MRI spectroscopy investigati ons were performed on all the pati ents. The lipid levels of all pati ents were recorded. In pathological investigati on, the rati o of the number of cells stained by Ki 67 nucle ar staining to the number of all the cells was calculated in terms of a percentage. The associ ati on between lipid levels and the Ki 67 index of cases was analysed.

Results:
There was no significant relati onship between age, gender and the Ki 67 index and lipid levels of cases. It was significant to have a value of 350 as the lowest lipid level in GBM. There was no significant relati onship between the Ki 67 index and lipid levels.

Conclusi ons:
The Ki 67 index has no value in determinati on of a tre atment strategy in cases di agnosed with GBM. Therefore, we do not beli eve that the Ki 67 index study sho uld be a ro utine laboratory investigati on in cases with GBM.

Key words:
gli oblastoma multiforme –  Ki 67 index –  lipid level –  MRI spectroscopy

Metin Kaplan, MD
Firat Universitesi, Tip Fakultesi
Norosirurji AD, Firat Tip Merkezi
23200 Elazig, Turkiye
e‑mail: mtkaplan02@yahoo.com.tr


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Labels
Paediatric neurology Neurosurgery Neurology

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Czech and Slovak Neurology and Neurosurgery

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