Assessment of Life Satisfaction in Patients with Clinically Isolated Syndrome

Authors: E. Hynčicová 1;  M. Vyhnálek 1;  
t. Nikolai 1;  J. Hort 1;  
e. Meluzínová 1;  J. Laczó 1
Authors‘ workplace: Neurologická klinika 2. LF UK a FN Motol, Praha 1
Published in: Cesk Slov Neurol N 2017; 80(6): 675-678
Category: Original Paper


Our aim was to evaluate life satisfaction in patients with clinically isolated syndrome (CIS) and its association with depression, anxiety, cognitive difficulties and severity of disability.

Subjects and methods:
We assessed life satisfaction with Questionnaire of Life Satisfaction (QLS), cognitive difficulties with Multiple Sclerosis Neuropsychological Screening Questionnaire (MSNQ), depression and anxiety with Beck Depression Inventory (BDΙ) and Beck Anxiety Inventory (BAI) in 60 patients with CIS and 42 healthy volunteers. The Expanded Disability Status Scale (EDSS) was used to evaluate severity of disability in patients with CIS.

We found lower total QLS score and lower specific QLS subscores (evaluation of health, marriage and partnership and sexuality) in patients with CIS compared to controls (p ≤ 0.048). Patients with CIS had higher BDI and BAI scores compared to controls (p ≤ 0.026). We also found negative correlation between scores for BDI, BAI and MSNQ, total QLS score and the specific QLS subscores in patients with CIS (rsp ≤ –0.260; p ≤ 0.045). EDSS was negatively correlated with QLS subscore “evaluation of work and employment” (rsp = –0.267; p = 0.041).

In this study, we found lower life satisfaction in patients with CIS who are at high risk of developing multiple sclerosis. Lower life satisfaction in patients with CIS was more strongly associated with severity of depressive and anxiety symptoms and cognitive difficulties than with severity of disability.

Key words:
multiple sclerosis – clinically isolated syndrome – life satisfaction – anxiety – depression – cognitive difficulties – disability

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Chinese summary - 摘要







与对照组相比,CIS患者的QLS总体评分和部分QLS子项评分较低(健康状况,婚姻状况和合作关系以及性行为评估)(p≤0.048);BDI和BAI评分较高(p≤0.026)。我们还发现CIS患者的BDI,BAI和MSNQ得分、QLS总体得分和部分具体QLS得分之间呈负相关(rsp≤-0.260;p≤0.045)。EDSS与QLS “工作和就业评估”子项目分数呈负相关(rsp = -0.267; p = 0.041)。




多发性硬化症 - 临床孤立综合征 - 生活满意度 - 焦虑 - 抑郁 - 认知障碍 - 残疾


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