Treatment targeted for B lymphocytes – significant progress in the treatment of multiple sclerosis

Authors: J. Piťha
Authors‘ workplace: Neurologické oddělení, Krajská zdravotní, a. s. – Nemocnice Teplice o. z., Teplice ;  Neurologická klinika 1. LF UK a VFN Praha
Published in: Cesk Slov Neurol N 2018; 81(4): 395-402
Category: Review Article
doi: 10.14735/amcsnn2018395


The article summarizes the findings regarding the complex involvement of B lymphocytes in the development and maintenance of autoimmune inflammation in MS. Substances that cause B cell depletion are mentioned. The greatest attention is paid to ocrelizumab, its mechanism of action, the results of clinical trials and adverse effects. Ocrelizumab is the first monoclonal antibody that targets B cells that are significantly involved in the immunopathogenesis of MS. It is approved for the treatment of patients with relapsing remitting, but also primary, progressive MS. Ocrelizumab is a drug with excellent adherence and a very good benefit/risk ratio.

Key words:
multiple sclerosis – ocrelizumab – B cells – biological treatment – NEDA

The author declare he has no potential con­flicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.


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