Classification of Central Nervous System Tumors – WHO 2016 Update

Authors: J. Polívka 1;  T. Řepík 1;  L. Holubec 2;  J. Polívka jr. 1 3
Authors‘ workplace: Neurologická klinika LF UK a FN Plzeň 1;  Biomedicínské centrum, LF UK v Plzni 2;  Ústav histologie a embryologie LF UK v Plzni 3
Published in: Cesk Slov Neurol N 2017; 80/113(3): 353-356

Podporováno projektem Ministerstva zdravotnictví České republiky pro konceptuální rozvoj výzkumné organizace 00669806 –  Fakultní nemocnice Plzeň.
Podporováno z Národního program udržitelnosti I (NPU I) č. LO1503 poskytovaného Ministerstvem školství, mládeže a tělovýchovy ČR.
Podporováno grantem SVV 2016 č. 260 283.
Podporováno Programem rozvoje vědních oborů Univerzity Karlovy (Progres Q39).


Recently updated classification of the central nervous system (CNS) tumours prepared by the World Health Organization (WHO) in 2016 uses, in addition to the histopathological criteria, also molecular genetic characteristics (biomarkers) of tumour cells and introduces the so-called integrated diagnostics concept for the first time. Molecular genetic biomarkers often have a major impact on the patients´ prognosis and/or selection of an appropriate therapy in a variety of tumour entities. This update represents a significant progress compared to the 2007 classification of CNS tumours. The more precise classification of tumours using well-known and widely accepted molecular genetic biomarkers, will also facilitate further research in anticancer therapeutics and consistent inclusion of patients into clinical trials. The presence of a tumour group called „not otherwise specified“ (NOS) is the major drawback of this novel approach. Tumours currently classified as the NOS entities are likely to be more accurately characterized with an ongoing neurooncological research in molecular genetics. The operational and technical barriers of molecular genetic analyses will be also overcome and this will further enable significant reduction of the NOS tumour entities. It is assumed that the new classification will facilitate clinical, experimental as well as epidemiological studies and thereby will improve the life of patients with brain tumours. This review presents the key findings from the new classification of the CNS tumours together with their clinical sequelae.

Key words:
CNS tumors – classification 2016 – WHO – IDH mutation – 1p/19q co-deletion – integrated diagnostics – molecular genetics – personalized medicine

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.


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