Results of Endocrine Function after Transsphenoidal Surgery for Non-functional Pituitary Macroadenomas

Authors: V. Novák 1;  L. Hrabálek 1;  Z. Fryšák 2;  J. Hoza 3;  C. Hučko 3;  D. Krahulík 1;  J. Macháč 1;  M. Vaverka 1
Authors‘ workplace: Neurochirurgická klinika LF UP a FN Olomouc 1;  III. interní klinika – nefrologická revmatologická a endokrinologická LF UP a FN Olomouc 2;  Otolaryngologická klinika FN a LF UP Olomouc 3
Published in: Cesk Slov Neurol N 2017; 80/113(3): 286-290
Category: Original Paper
doi: 10.14735/amcsnn2017286

Článek nebyl podpořen formou grantu, přístrojového vybavení nebo léků.


The aim of this study was to assess changes to endocrine pituitary function following pituitary macroadenoma surgery and to compare the microscopic and endoscopic techniques.

A study group included patients with nonfunctional pituitary macroadenoma undergoing microscopic or endoscopic transnasal transsphenoidal approach at the Department of Neurosurgery of the University Hospital in Olomouc. All patients underwent neurologic, radiologic and endocrinology examination before and after surgery. All data were retrospectively reviewed and both techniques were statistically compared.

A total of 78 patients were included in this study. In patients without preoperative hormonal abnormalities, postoperative deficit occurred more often in the microscope group (47.4%) compared to endoscopic group (40%) but the difference was not statistically significant (p = 0.761). In patients with a preoperative hormonal abnormality, postoperative deterioration of hormonal functions was more frequent again in the microscope-operated (70%) compared to the endoscopic group (21.4%), the difference was statistically significant (p = 0.015).

In our study, endoscopic technique achieves better postoperative results of pituitary hormonal functions compared to microscopic techniques, particularly in patients with preoperative hormonal abnormality.

Key words:
hypopituitarism – transsphenoidal surgery – nonfunctional pituitary adenoma – endocrine deficit

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Chinese summary - 摘要







本研究共纳入78例患者。术前激素异常患者术后缺血发生率明显高于内镜组(40%),差异无统计学意义(P = 0.761)。术前激素异常患者术后,与内窥镜组比较(21.4%),显微手术(70%),术后激素功能下降更为频繁,差异有统计学意义(p = 0.015)。




垂体功能减退症 - 经蝶窦手术 - 非功能垂体腺瘤 - 内分泌缺陷


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