A comparative study of myasthenic patients in the Czech and Slovak Republics


Authors: M. Horáková 1;  I. Martinka 2;  S. Voháňka 3;  P. Špalek 2;  J. Bednařík 3
Published in: Cesk Slov Neurol N 2019; 82(2): 171-175
Category: Original Paper
doi: 10.14735/amcsnn2019171

Overview

Aim: Exist­­ing epidemiological studies of myasthenia feature dif­ferences in incidence, prevalence, age- and gender-specific incidences, mortality rate, and even the prevalence of myasthenia subtypes. The aim of this study was to compare the over­all management of patients with myasthenia, the severity of the dis­ease, and a number of clinical and laboratory characteristics and ther­apy approaches amongst patients in the Czech Republic and the Slovak Republic.

Patients and methods: Data were retrospectively col­lected from two registries in the Czech Republic (Brno) and the Slovak Republic (Bratislava). Data were randomly matched by age of onset of myasthenia and gender. The result­­ing groups consisted of 152 patients each.

Results: There was almost no significant dif­ference between the matched groups. The clinical form, positivity of antibodies to acetylcholine receptor, Myasthenia Gravis Composite Score, time to dia­gnosis, and percentage of thymomas and thymectomy were not significantly dif­ferent. There were significant dif­ferences only in the occur­rence of limb weakness at the onset of dis­ease and in the choice of treatment modality.

Conclusions: Our data suggest that at least part of previously observed heterogeneity between populations might be based on dif­ferent age and gender distribution.

Keywords:

myasthenia gravis – population characteristics – comparison – registries


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Paediatric neurology Neurosurgery Neurology

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