Multiple sclerosis and pregnancy from a gynecologist‘s perspective – as sisted reproduction options

Authors: P. Hanulíková 1,2;  T. Mardešić 3
Authors‘ workplace: Ústav pro péči o matku a dítě, Praha 1;  LF v Plzni, UK 2;  Sanatorium Pronatal, Praha 3
Published in: Cesk Slov Neurol N 2019; 82(2): 155-159
Category: Review Article


The incidence of MS is increasing, especial­ly in young women (20– 40 years). As incidence increases, experience in the management of pregnancies in these patients also accumulates. Dur­­ing pregnancy, the risk of relapse declines continuously especial­ly in the third trimester. After childbirth, disease activity after temporary increase (3 months) returns to pre-pregnancy levels at about 6 months. Use of dis­ease-modify­­ing ther­apy (DMT) in women with MS leads to clinical dis­ease stabilization, mak­­ing it ideal conditions for plan­ned conception. MS patients may use the majority of contraceptive methods while be­­ing under DMT. The course of MS is not influenced by pregnancy, and the care of pregnant women and neonatal outcomes are similar to that of women without MS. Due to the frequency of fertility disorders in the population, this is­sue also af­fects patients with MS, where dur­­ing the period of stabilization of the dis­ease the methods of as­sisted reproduction can be used.

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manu­script met the ICMJE “uniform requirements” for biomedical papers.


Multiple sclerosis – pregnancy – childbirth – assisted reproduction


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